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Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics

Overview of attention for article published in Journal of Microencapsulation, June 2009
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6 Wikipedia pages

Citations

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161 Dimensions

Readers on

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108 Mendeley
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Title
Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics
Published in
Journal of Microencapsulation, June 2009
DOI 10.1080/02652040802312572
Pubmed ID
Authors

Rakesh Kumar Tekade, Tathagata Dutta, Virendra Gajbhiye, Narendra Kumar Jain

Abstract

A major problem associated with conventional leukaemia chemotherapy is the development of resistance that can be surmounted well by combination chemotherapy. The objective of the present investigation is to report a novel technology to load two anti-leukaemic drugs of choice simultaneously inside the PAMAM dendrimer. Under optimized conditions of pH and dialysis time, one molecule of PAMAM dendrimer was found to be capable of entrapping 27.02 ± 0.51 and 8.00 ± 0.46 molecules of Methotrexate and all-trans Retinoic acid (ATRA), respectively. The simultaneous in-vitro release profiling of the loaded drugs was studied at pH 4, 7.4 and 10. The release kinetics was found to be governed by degree of dendrimer protonation, with more sustained and controlled behaviour at pH 7.4. Terminal loading of dendrimer with less haemolytic bioactive (ATRA) reduced the haemolytic toxicity of the dendrimer formulation. A cytotoxicity study was performed on HeLa cell lines by MTT assay, wherein after 72 h, the dual-drug loaded dendrimer was found to be more efficient (IC(50) 0.5 µM) as compared to that of the free drug combination (IC(50) 0.75 µM).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 2%
Unknown 106 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 23%
Student > Master 17 16%
Researcher 11 10%
Student > Bachelor 8 7%
Student > Doctoral Student 3 3%
Other 13 12%
Unknown 31 29%
Readers by discipline Count As %
Chemistry 16 15%
Biochemistry, Genetics and Molecular Biology 12 11%
Pharmacology, Toxicology and Pharmaceutical Science 11 10%
Engineering 9 8%
Medicine and Dentistry 7 6%
Other 17 16%
Unknown 36 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2022.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Journal of Microencapsulation
#191
of 704 outputs
Outputs of similar age
#38,268
of 113,852 outputs
Outputs of similar age from Journal of Microencapsulation
#10
of 28 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 704 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 113,852 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.