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Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Overview of attention for article published in Science, February 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
25 news outlets
blogs
8 blogs
twitter
437 X users
patent
4 patents
facebook
7 Facebook pages
googleplus
1 Google+ user
reddit
1 Redditor
video
1 YouTube creator

Citations

dimensions_citation
872 Dimensions

Readers on

mendeley
894 Mendeley
citeulike
2 CiteULike
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Title
Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics
Published in
Science, February 2018
DOI 10.1126/science.aaq1144
Pubmed ID
Authors

Shuo Chen, Adam Z Weitemier, Xiao Zeng, Linmeng He, Xiyu Wang, Yanqiu Tao, Arthur J Y Huang, Yuki Hashimotodani, Masanobu Kano, Hirohide Iwasaki, Laxmi Kumar Parajuli, Shigeo Okabe, Daniel B Loong Teh, Angelo H All, Iku Tsutsui-Kimura, Kenji F Tanaka, Xiaogang Liu, Thomas J McHugh

Abstract

Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 437 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 894 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 894 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 199 22%
Researcher 148 17%
Student > Master 82 9%
Student > Bachelor 78 9%
Student > Doctoral Student 46 5%
Other 134 15%
Unknown 207 23%
Readers by discipline Count As %
Neuroscience 177 20%
Agricultural and Biological Sciences 85 10%
Engineering 84 9%
Chemistry 65 7%
Biochemistry, Genetics and Molecular Biology 59 7%
Other 184 21%
Unknown 240 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 491. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#53,988
of 25,584,565 outputs
Outputs from Science
#2,094
of 83,124 outputs
Outputs of similar age
#1,340
of 452,829 outputs
Outputs of similar age from Science
#71
of 1,179 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,124 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,179 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.