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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Brain–behavior patterns define a dimensional biotype in medication-naïve adults with attention-deficit hyperactivity disorder
|
|---|---|
| Published in |
Psychological Medicine, February 2018
|
| DOI | 10.1017/s0033291718000028 |
| Pubmed ID | |
| Authors |
Hsiang-Yuan Lin, Luca Cocchi, Andrew Zalesky, Jinglei Lv, Alistair Perry, Wen-Yih Isaac Tseng, Prantik Kundu, Michael Breakspear, Susan Shur-Fen Gau |
| Abstract |
Childhood-onset attention-deficit hyperactivity disorder (ADHD) in adults is clinically heterogeneous and commonly presents with different patterns of cognitive deficits. It is unclear if this clinical heterogeneity expresses a dimensional or categorical difference in ADHD. We first studied differences in functional connectivity in multi-echo resting-state functional magnetic resonance imaging (rs-fMRI) acquired from 80 medication-naïve adults with ADHD and 123 matched healthy controls. We then used canonical correlation analysis (CCA) to identify latent relationships between symptoms and patterns of altered functional connectivity (dimensional biotype) in patients. Clustering methods were implemented to test if the individual associations between resting-state brain connectivity and symptoms reflected a non-overlapping categorical biotype. Adults with ADHD showed stronger functional connectivity compared to healthy controls, predominantly between the default-mode, cingulo-opercular and subcortical networks. CCA identified a single mode of brain-symptom co-variation, corresponding to an ADHD dimensional biotype. This dimensional biotype is characterized by a unique combination of altered connectivity correlating with symptoms of hyperactivity-impulsivity, inattention, and intelligence. Clustering analyses did not support the existence of distinct categorical biotypes of adult ADHD. Overall, our data advance a novel finding that the reduced functional segregation between default-mode and cognitive control networks supports a clinically important dimensional biotype of childhood-onset adult ADHD. Despite the heterogeneity of its presentation, our work suggests that childhood-onset adult ADHD is a single disorder characterized by dimensional brain-symptom mediators. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 50% |
| United Kingdom | 1 | 25% |
| China | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 18% |
| Student > Master | 17 | 18% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Doctoral Student | 6 | 6% |
| Student > Bachelor | 5 | 5% |
| Other | 16 | 17% |
| Unknown | 19 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 20 | 21% |
| Neuroscience | 16 | 17% |
| Medicine and Dentistry | 10 | 11% |
| Computer Science | 5 | 5% |
| Social Sciences | 3 | 3% |
| Other | 11 | 12% |
| Unknown | 29 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2018.
All research outputs
#6,736,385
of 25,382,250 outputs
Outputs from Psychological Medicine
#2,548
of 5,440 outputs
Outputs of similar age
#126,182
of 450,616 outputs
Outputs of similar age from Psychological Medicine
#42
of 75 outputs
Altmetric has tracked 25,382,250 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 5,440 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,616 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.