| Title |
Blocking of Striated Muscle Degeneration by Serotonin in C. elegans
|
|---|---|
| Published in |
Journal of Muscle Research and Cell Motility, June 2006
|
| DOI | 10.1007/s10974-006-9070-9 |
| Pubmed ID | |
| Authors |
Maité Carre-Pierrat, Marie-Christine Mariol, Lucie Chambonnier, Aurélie Laugraud, Fabienne Heskia, Jean Giacomotto, Laurent Ségalat |
| Abstract |
Prevention of muscle fiber degeneration is a key issue in the treatment of muscular dystrophies such as Duchenne Muscular Dystrophy (DMD). It is widely postulated that existing pharmaceutical compounds might potentially be beneficial to DMD patients, but tools to identify them are lacking. Here, by using a Caenorhabditis elegans model of dystrophin-dependent muscular dystrophy, we show that the neurohormone serotonin and some of its agonists are potent suppressors of muscle degeneration. Inhibitors of serotonin reuptake transporters, which prolong the action of endogenous serotonin, have a similar effect. Moreover, reduction of serotonin levels leads to degeneration of non-dystrophic muscles. Our results demonstrate that serotonin is critical to C. elegans striated muscles. These findings reveal a new function of serotonin in striated muscles. |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 26% |
| Student > Ph. D. Student | 6 | 18% |
| Student > Master | 6 | 18% |
| Other | 2 | 6% |
| Student > Bachelor | 2 | 6% |
| Other | 4 | 12% |
| Unknown | 5 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 38% |
| Biochemistry, Genetics and Molecular Biology | 6 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Engineering | 2 | 6% |
| Environmental Science | 1 | 3% |
| Other | 4 | 12% |
| Unknown | 6 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2015.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Journal of Muscle Research and Cell Motility
#69
of 295 outputs
Outputs of similar age
#22,476
of 64,015 outputs
Outputs of similar age from Journal of Muscle Research and Cell Motility
#1
of 2 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 295 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them