| Title |
Neurotrophin signaling: many exciting surprises!
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, May 2006
|
| DOI | 10.1007/s00018-006-6010-1 |
| Pubmed ID | |
| Authors |
J. C. Arévalo, S. H. Wu |
| Abstract |
Neurotrophins are growth factors implicated in the development and maintenance of different neuronal populations in the nervous system. Neurotrophins bind to two sets of receptors, Trk receptor tyrosine kinases and the p75NTR receptor, to activate several different signaling pathways that mediate various biological functions. While Trk receptor activation has been well-studied and triggers the well-characterized Ras/Rap-MAPK, PI3K-Akt, and PLCgamma-PKC cascades, p75NTR signaling is more complex, and its in vivo significance has not yet been completely determined. In the last few years, p75NTR has received much attention mainly due to recent findings describing pro-neurotrophins as new ligands for the receptor and the ability of the receptor to form different complexes with other transmembrane proteins. This review will update the neurotrophin signaling pathways known for Trk receptors to include newly identified Trk-interacting molecules and will address surprising new findings that suggest a role for p75NTR in different receptor complexes and functions. |
Mendeley readers
The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| France | 2 | <1% |
| United Kingdom | 2 | <1% |
| Finland | 1 | <1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Belgium | 1 | <1% |
| Taiwan | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 192 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 27% |
| Researcher | 28 | 14% |
| Student > Master | 28 | 14% |
| Student > Bachelor | 20 | 10% |
| Student > Doctoral Student | 11 | 5% |
| Other | 28 | 14% |
| Unknown | 35 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 75 | 37% |
| Biochemistry, Genetics and Molecular Biology | 28 | 14% |
| Medicine and Dentistry | 27 | 13% |
| Neuroscience | 25 | 12% |
| Sports and Recreations | 2 | <1% |
| Other | 7 | 3% |
| Unknown | 41 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2023.
All research outputs
#4,965,094
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#928
of 4,151 outputs
Outputs of similar age
#12,412
of 66,977 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#11
of 39 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,977 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.