| Title |
Signal transduction through the sphingomyelin pathway
|
|---|---|
| Published in |
Journal of Molecular Neuroscience, February 1994
|
| DOI | 10.1007/bf02815356 |
| Pubmed ID | |
| Authors |
Richard Kolesnick |
| Abstract |
The sphingomyelin pathway is a new signal transduction system initiated by hydrolysis of plasma membrane sphingomyelin to ceramide by the actin of a neutral sphingomyelinase. Ceramide serine/threonine protein kinase termed ceramide-activated protein kinase. This kinase belongs to a family of proline-directed protein kinases that recognize substrates containing the minimal motif, X-Thr/Ser-Pro-X, where the phosphoacceptor site is followed on the carboxyl terminus by a proline residue and X may be any amino acid. Three lines of evidence, rapid kinetics of activation of the sphingomyelin pathway by tumor necrosis factor (TNF) alpha, the ability of cell-permeable ceramide analogs to bypass receptor activation and mimic the effect of TNF alpha, and reconstitution of this cascade in a cell-free system, support the concept that the sphingomyelin pathway serves to signal TNF alpha-induced monocytic differentiation. Hence, the sphingomyelin pathway may represent a signaling system analogous to more well-defined systems such as the cyclic adenosine monophosphate and phosphoinositide pathways. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 6% |
| Canada | 1 | 3% |
| Unknown | 29 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 19% |
| Student > Ph. D. Student | 6 | 19% |
| Student > Doctoral Student | 5 | 16% |
| Student > Bachelor | 5 | 16% |
| Student > Master | 4 | 13% |
| Other | 3 | 9% |
| Unknown | 3 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 28% |
| Biochemistry, Genetics and Molecular Biology | 8 | 25% |
| Physics and Astronomy | 2 | 6% |
| Chemistry | 2 | 6% |
| Medicine and Dentistry | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 5 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2012.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Journal of Molecular Neuroscience
#485
of 1,643 outputs
Outputs of similar age
#14,628
of 72,132 outputs
Outputs of similar age from Journal of Molecular Neuroscience
#3
of 10 outputs
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So far Altmetric has tracked 1,643 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
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