| Title |
Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, February 2008
|
| DOI | 10.1007/s10555-008-9118-y |
| Pubmed ID | |
| Authors |
Samir Kumar Patra, Aditi Patra, Federica Rizzi, Tapash Chandra Ghosh, Saverio Bettuzzi |
| Abstract |
Cancer cells and tissues exhibit genome wide hypomethylation and regional hypermethylation. CpG-methylation of DNA ((Me)CpG-DNA) is defined as the formation of a C-C covalent bond between the 5'-C of cytosine and the -CH(3) group of S-adenosylmethionine. Removal of the sole -CH(3) group from the methylated cytosine of DNA is one of the many ways of DNA-demethylation, which contributes to activation of transcription. The mechanism of demethylation, the candidate enzyme(s) exhibiting direct demethylase activity and associated cofactors are not firmly established. Genome-wide hypomethylation can be obtained in several ways by inactivation of DNMT enzyme activity, including covalent trapping of DNMT by cytosine base analogues. Removal of methyl layer could also be occurred by excision of the 5-methyl cytosine base by DNA glycosylases. The importance of truly chemically defined direct demethylation of intact DNA in regulation of gene expression, development, cell differentiation and transformation are discussed in this contribution. |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 4% |
| Spain | 2 | 3% |
| United States | 2 | 3% |
| Hungary | 1 | 1% |
| Unknown | 62 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 27% |
| Student > Ph. D. Student | 18 | 26% |
| Student > Master | 7 | 10% |
| Student > Bachelor | 5 | 7% |
| Professor > Associate Professor | 4 | 6% |
| Other | 11 | 16% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 47% |
| Biochemistry, Genetics and Molecular Biology | 11 | 16% |
| Medicine and Dentistry | 8 | 11% |
| Chemistry | 4 | 6% |
| Business, Management and Accounting | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2016.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Cancer and Metastasis Reviews
#286
of 807 outputs
Outputs of similar age
#42,776
of 156,322 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#4
of 9 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 807 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,322 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.