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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neurogenic differentiation by hippocampal neural stem and progenitor cells is biased by NFIX expression
|
|---|---|
| Published in |
Development (09501991), February 2018
|
| DOI | 10.1242/dev.155689 |
| Pubmed ID | |
| Authors |
Lachlan Harris, Oressia Zalucki, Olivier Clément, James Fraser, Elise Matuzelski, Sabrina Oishi, Tracey J. Harvey, Thomas H. J. Burne, Julian Ik-Tsen Heng, Richard M. Gronostajski, Michael Piper |
| Abstract |
Our understanding of the transcriptional programme underpinning adult hippocampal neurogenesis is incomplete. In mice, under basal conditions, adult hippocampal neural stem cells (AH-NSCs) generate neurons and astrocytes, but not oligodendrocytes. The factors limiting oligodendrocyte production, however, remain unclear. Here, we reveal that the transcription factor NFIX plays a key role in this process. NFIX is expressed by AH-NSCs, and its expression is sharply upregulated in adult hippocampal neuroblasts. Conditional ablation of Nfix from AH-NSCs, coupled with lineage tracing, transcriptomic sequencing and behavioural studies collectively reveal that NFIX is cell-autonomously required for neuroblast maturation and survival. Moreover, a small number of AH-NSCs also develop into oligodendrocytes following Nfix deletion. Remarkably, when Nfix is deleted specifically from intermediate progenitor cells and neuroblasts using a Dcx-creERT2 driver, these cells also display elevated signatures of oligodendrocyte gene expression. Together, these results demonstrate the central role played by NFIX in neuroblasts within the adult hippocampal stem cell neurogenic niche in promoting the maturation and survival of these cells, while concomitantly repressing oligodendrocyte gene expression signatures. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 33% |
| United States | 1 | 17% |
| Congo, The Democratic Republic of the | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 25% |
| Student > Master | 8 | 17% |
| Researcher | 8 | 17% |
| Student > Doctoral Student | 4 | 8% |
| Student > Postgraduate | 4 | 8% |
| Other | 7 | 15% |
| Unknown | 5 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 40% |
| Biochemistry, Genetics and Molecular Biology | 9 | 19% |
| Agricultural and Biological Sciences | 8 | 17% |
| Computer Science | 2 | 4% |
| Chemical Engineering | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 6 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2021.
All research outputs
#5,311,777
of 25,382,440 outputs
Outputs from Development (09501991)
#3,261
of 9,469 outputs
Outputs of similar age
#109,197
of 446,427 outputs
Outputs of similar age from Development (09501991)
#127
of 307 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,469 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,427 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 307 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.