| Title |
Modulation of gut microbiota by dietary supplementation with tuna oil and algae oil alleviates the effects of D-galactose-induced ageing
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, February 2018
|
| DOI | 10.1007/s00253-018-8775-1 |
| Pubmed ID | |
| Authors |
Hongyan Zhang, Yanyan Li, Chenxi Cui, Tingting Sun, Jiaojiao Han, Dijun Zhang, Chenyang Lu, Jun Zhou, Lingzhi Cheong, Ye Li, Xiurong Su |
| Abstract |
Previous studies have shown that dietary supplementation with tuna oil and algae oil can alleviate the effects of ageing on learning and memory in mouse models, but the mechanism of this effect remains unknown. This study aimed to determine whether dietary oil supplementation alters the composition of the gut microbiota during the prevention of age-related effects on cognition. Ageing mice received dietary oil supplementation continuously for 12 weeks. The supplementation was found to improve the animals' learning and cognition, and this effect was most marked in the TO200AO400 group, which received a 1:2 mixture of tuna oil and algae oil at 600 mg kg-1 day-1. Next-generation sequencing of the 16S rRNA gene present in faecal samples showed that the gut microbiota varied in the groups that received different oil treatments; the TO200AO400 treatment most closely restored the composition of the D-galactose-altered gut microbiota to that of the control. Moreover, 83 altered operational taxonomic units (OTUs) responsive to dietary oil supplementation were identified; five of these differed in one or more parameters associated with host ageing. In conclusion, this study confirmed the effect of dietary oil supplementation on the alleviation of age-related decline in cognitive function and showed that oil supplementation results in alterations in the composition of the gut microbiota. Further research will be needed to elucidate the causal relationship between the reversal of age-related cognitive decline and gut microbiota modulation and to explore the potential of gut microbial communities as a diagnostic biomarker and a therapeutic target in ageing. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 4 | 18% |
| United States | 3 | 14% |
| India | 3 | 14% |
| Spain | 1 | 5% |
| Netherlands | 1 | 5% |
| New Zealand | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 8 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 55% |
| Scientists | 6 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
| Science communicators (journalists, bloggers, editors) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 23% |
| Student > Doctoral Student | 4 | 10% |
| Student > Ph. D. Student | 3 | 8% |
| Student > Master | 3 | 8% |
| Student > Postgraduate | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 12 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 21% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Immunology and Microbiology | 3 | 8% |
| Nursing and Health Professions | 3 | 8% |
| Environmental Science | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 16 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2018.
All research outputs
#1,855,180
of 24,885,505 outputs
Outputs from Applied Microbiology and Biotechnology
#120
of 8,165 outputs
Outputs of similar age
#43,173
of 448,410 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#2
of 132 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,165 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 132 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.