Title |
造血幹細胞の老化
|
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Published in |
[Rinshō ketsueki] The Japanese journal of clinical hematology, January 2018
|
DOI | 10.11406/rinketsu.59.3 |
Pubmed ID | |
Authors |
Hiroko Shiozaki, Ayako Nakamura-Ishizu, Toshio Suda |
Abstract |
The frequency of clonal hematopoiesis in humans vastly increases with aging. Older adults may develop one or several clones and this condition is called clonal hematopoiesis of indeterminate potential (CHIP). Recent genetic analyses have identified the genes inducing CHIP. These mutant genes are detected frequently in elderly people and this condition is a precursor of hematopoietic neoplasms. The prevalence of hematopoietic neoplasms in patients with CHIP is tenfold that in those without CHIP. Consequently, the mechanism of aging and leukemogenesis of hematopoietic stem cells is being understood. Furthermore, the efficacy of senolysis, selectively removing scenescent cells from tissues, has been demonstrated in mice. The clinical application of senolysis is anticipated shortly. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 2 | 25% |
Other | 1 | 13% |
Student > Ph. D. Student | 1 | 13% |
Researcher | 1 | 13% |
Professor > Associate Professor | 1 | 13% |
Other | 0 | 0% |
Unknown | 2 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 2 | 25% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
Psychology | 1 | 13% |
Nursing and Health Professions | 1 | 13% |
Unknown | 3 | 38% |