| Title |
Regeneration of functional alveoli by adult human SOX9+ airway basal cell transplantation
|
|---|---|
| Published in |
Protein & Cell, January 2018
|
| DOI | 10.1007/s13238-018-0506-y |
| Pubmed ID | |
| Authors |
Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo |
| Abstract |
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. Human SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition. Expanded human SOX9+ BCs can give rise to alveolar and bronchiolar epithelium after being transplanted into injured mouse lung, with air-blood exchange system reconstructed and recipient's lung function improved. Manipulation of lung microenvironment with Pirfenidone to suppress TGF-β signaling could further boost the transplantation efficiency. Moreover, we conducted the first autologous SOX9+ BCs transplantation clinical trial in two bronchiectasis patients. Lung tissue repair and pulmonary function enhancement was observed in patients 3-12 months after cell transplantation. Altogether our current work indicated that functional adult human lung structure can be reconstituted by orthotopic transplantation of tissue-specific stem/progenitor cells, which could be translated into a mature regenerative therapeutic strategy in near future. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 24% |
| France | 4 | 19% |
| Mexico | 1 | 5% |
| Guinea | 1 | 5% |
| Spain | 1 | 5% |
| Moldova, Republic of | 1 | 5% |
| Germany | 1 | 5% |
| Unknown | 7 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 71% |
| Scientists | 5 | 24% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 22% |
| Researcher | 12 | 13% |
| Student > Bachelor | 9 | 10% |
| Student > Master | 8 | 9% |
| Student > Postgraduate | 4 | 4% |
| Other | 15 | 16% |
| Unknown | 25 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 19% |
| Agricultural and Biological Sciences | 14 | 15% |
| Biochemistry, Genetics and Molecular Biology | 13 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Immunology and Microbiology | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 26 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 144. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2023.
All research outputs
#280,315
of 25,051,161 outputs
Outputs from Protein & Cell
#12
of 807 outputs
Outputs of similar age
#6,624
of 453,551 outputs
Outputs of similar age from Protein & Cell
#1
of 11 outputs
Altmetric has tracked 25,051,161 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 807 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,551 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.