| Title |
Linking the Gut Microbiota to Bone Health in Anorexia Nervosa
|
|---|---|
| Published in |
Current Osteoporosis Reports, February 2018
|
| DOI | 10.1007/s11914-018-0420-5 |
| Pubmed ID | |
| Authors |
Nicole C. Aurigemma, Kristen J. Koltun, Hannah VanEvery, Connie J. Rogers, Mary Jane De Souza |
| Abstract |
The purpose of this review is to examine the anorexia nervosa-microbiota-bone relationship, offering a compilation of the relevant human and animal studies that may contribute to a more comprehensive understanding of potential mechanisms involved. Recent studies have implicated fermentation by-products of the gut microbiota in bone metabolism. Compromised bone health often accompanies anorexia nervosa due to energy deficiency and hypoestrogenism. The gut microbiome has been implicated as a link between these conditions and impaired bone growth phenotypes. Current research supports decrements in Firmicutes and short-chain fatty acids with increases in Methanobrevibacter smithii and Proteobacteria in anorexia nervosa. A potential mechanism for microbiome-regulated bone growth is through modulation of insulin-like growth factor-1. Future research should aim to examine short-chain fatty acids, probiotics, and prebiotics as alternative therapies to treat low bone density in anorexia nervosa. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 23% |
| Netherlands | 1 | 8% |
| New Zealand | 1 | 8% |
| Spain | 1 | 8% |
| India | 1 | 8% |
| Unknown | 6 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 69% |
| Scientists | 2 | 15% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 92 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 16% |
| Researcher | 12 | 13% |
| Student > Master | 11 | 12% |
| Student > Doctoral Student | 7 | 8% |
| Student > Ph. D. Student | 6 | 7% |
| Other | 17 | 18% |
| Unknown | 24 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 18% |
| Nursing and Health Professions | 10 | 11% |
| Agricultural and Biological Sciences | 9 | 10% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Neuroscience | 4 | 4% |
| Other | 15 | 16% |
| Unknown | 29 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2018.
All research outputs
#2,313,607
of 24,885,505 outputs
Outputs from Current Osteoporosis Reports
#40
of 597 outputs
Outputs of similar age
#52,785
of 448,410 outputs
Outputs of similar age from Current Osteoporosis Reports
#1
of 18 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 597 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.