| Title |
The effect of high dose barbiturate decompression after severe head injury. A controlled clinical trial
|
|---|---|
| Published in |
Acta Neurochirurgica, September 1984
|
| DOI | 10.1007/bf01406868 |
| Pubmed ID | |
| Authors |
H. K. Nordby, R. Nesbakken |
| Abstract |
Treatment resistant intracranial hypertension after severe head injury has a very high mortality with conventional therapy such as hyperventilation and mannitol infusions. In this report, we describe the use of large doses of thiopental as a means of treating such swelling. From a consecutive series of 107 severe head injuries with a Glasgow Coma Score (GCS) of 6 or below, we selected all patients below 40 years age with a progressive increase in intracranial pressure (ICP) to 40 mm Hg. The first 16 patients (mean age 20 years, mean GCS 4.3) were treated with deep barbiturate coma and hypothermia (32-35 degrees Celsius) until stable lowering of ICP was achieved. The next 15 patients received conventional intensive care and were in other respects very similar to the barbiturate group (mean age 26, mean GCS 5.2). After 9-12 months the outcome was classified according to the Glasgow Outcome Scale (GOS). Therapy with barbiturate coma resulted in 6 good/moderate outcomes, 3 severe and 7 dead/vegetative. Conventional treatment resulted in 2 good/moderate outcomes and 13 dead/vegetative. This is a highly significant difference and cannot easily be explained by more severe injuries or complications in the conventional group. Superior control of ICP was achieved by large doses of thiopental and the final outcome was better. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 24% |
| Other | 4 | 11% |
| Student > Ph. D. Student | 3 | 8% |
| Researcher | 3 | 8% |
| Lecturer | 2 | 5% |
| Other | 7 | 19% |
| Unknown | 9 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 30% |
| Neuroscience | 5 | 14% |
| Nursing and Health Professions | 2 | 5% |
| Engineering | 2 | 5% |
| Computer Science | 1 | 3% |
| Other | 6 | 16% |
| Unknown | 10 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2022.
All research outputs
#7,588,614
of 23,138,859 outputs
Outputs from Acta Neurochirurgica
#591
of 1,944 outputs
Outputs of similar age
#2,511
of 9,136 outputs
Outputs of similar age from Acta Neurochirurgica
#1
of 3 outputs
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