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Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets

Overview of attention for article published in Diabetologia, March 2006
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Title
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets
Published in
Diabetologia, March 2006
DOI 10.1007/s00125-006-0206-7
Pubmed ID
Authors

J. F. Paulsson, A. Andersson, P. Westermark, G. T. Westermark

Abstract

Islet amyloid is a frequent finding in the islets of Langerhans of individuals with type 2 diabetes. The main amyloid constituent is the beta cell-derived polypeptide hormone islet amyloid polypeptide (IAPP). In general, amyloid refers to an extracellular deposit of a congophilic material, but intracellular amyloid is seen in some beta cells of transgenic mice expressing the gene for human IAPP and in human islets transplanted into nude mice. The aim of this study was to immunohistochemically characterise the intracellular amyloid.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 76 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 29%
Student > Master 11 14%
Researcher 10 13%
Student > Bachelor 9 12%
Professor 2 3%
Other 3 4%
Unknown 20 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 29%
Agricultural and Biological Sciences 11 14%
Medicine and Dentistry 10 13%
Chemistry 5 6%
Immunology and Microbiology 1 1%
Other 6 8%
Unknown 22 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2022.
All research outputs
#7,413,245
of 22,663,969 outputs
Outputs from Diabetologia
#2,820
of 5,024 outputs
Outputs of similar age
#23,190
of 66,112 outputs
Outputs of similar age from Diabetologia
#18
of 43 outputs
Altmetric has tracked 22,663,969 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,024 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,112 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.