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Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE

Overview of attention for article published in American Journal of Neuroradiology, February 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

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Title
Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE
Published in
American Journal of Neuroradiology, February 2018
DOI 10.3174/ajnr.a5534
Pubmed ID
Authors

E.S. Beck, P. Sati, V. Sethi, T. Kober, B. Dewey, P. Bhargava, G. Nair, I.C. Cortese, D.S. Reich

Abstract

Cortical lesions are common and often extensive in multiple sclerosis but are difficult to visualize by MRI, leaving important questions about their clinical implications and response to therapy unanswered. Our aim was to determine whether cortical lesions are better visualized using magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) than T2*-weighted imaging on 7T MR imaging. Brain MR imaging using T1-weighted MP2RAGE at 500-μm isotropic resolution, T2*-weighted gradient-echo, and T2*-weighted segmented echo-planar imaging sequences were collected for 13 patients with MS and 5 age-matched neurologically healthy controls on a 7T research system. One MS case underwent postmortem MR imaging including gradient-echo and MP2RAGE sequences, after which cortical lesions seen on MR imaging were assessed with immunohistochemistry. MP2RAGE detected 203 cortical lesions (median, 16 lesions/case; interquartile range, 15), compared to 92 with T2*gradient-echo (median, 7; interquartile range, 8;P< .001) and 81 with T2*EPI (median, 7; interquartile range, 5;P< .001). This increase in lesion number detected on MP2RAGE versus T2* was observed for juxtacortical, leukocortical, and intracortical lesions. Forty-three percent of all cortical lesions were identified only on MP2RAGE. White matter lesion volume correlated with total juxtacortical (r= 0.86,P< .001) and leukocortical lesion volume (r= 0.70,P< .01) but not intracortical lesion volume, suggesting that pathophysiology may differ by lesion type. Of 4 suspected lesions seen on postmortem imaging, 3 were found to be true cortical lesions while 1 represented postmortem tissue damage. A combination of MP2RAGE and T2*-weighted imaging at 7T improved detection of cortical lesions and should enable longitudinal studies to elucidate their spatiotemporal dynamics and clinical implications.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 26%
Researcher 10 12%
Other 5 6%
Student > Master 5 6%
Professor 4 5%
Other 14 16%
Unknown 25 29%
Readers by discipline Count As %
Neuroscience 17 20%
Medicine and Dentistry 17 20%
Engineering 9 11%
Computer Science 4 5%
Physics and Astronomy 2 2%
Other 8 9%
Unknown 28 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#1,139,323
of 25,366,663 outputs
Outputs from American Journal of Neuroradiology
#114
of 5,242 outputs
Outputs of similar age
#26,923
of 452,293 outputs
Outputs of similar age from American Journal of Neuroradiology
#4
of 82 outputs
Altmetric has tracked 25,366,663 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,242 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.