| Title |
Cardiolipin, the heart of mitochondrial metabolism
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, April 2008
|
| DOI | 10.1007/s00018-008-8030-5 |
| Pubmed ID | |
| Authors |
R. H. Houtkooper, F. M. Vaz |
| Abstract |
Cardiolipin is a unique phospholipid, which is almost exclusively localized in the mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. After primary synthesis, the mature acyl chain composition of cardiolipin is achieved by at least two remodeling mechanisms. In the mitochondrial membrane cardiolipin plays an important role in energy metabolism, mainly by providing stability for the individual enzymes and enzyme complexes involved in energy production. Moreover, cardiolipin is involved in different stages of the mitochondrial apoptotic process and in mitochondrial membrane dynamics. Cardiolipin alterations have been described in various pathological conditions. Patients suffering from Barth syndrome have an altered cardiolipin homeostasis caused by a primary deficiency in cardiolipin remodeling. Alterations in cardiolipin content or composition have also been reported in more frequent diseases such as diabetes and heart failure. In this review we provide an overview of cardiolipin metabolism, function and its role in different pathological states. |
Mendeley readers
The data shown below were compiled from readership statistics for 376 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 1% |
| United Kingdom | 5 | 1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 363 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 95 | 25% |
| Researcher | 53 | 14% |
| Student > Master | 51 | 14% |
| Student > Bachelor | 44 | 12% |
| Student > Doctoral Student | 21 | 6% |
| Other | 52 | 14% |
| Unknown | 60 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 118 | 31% |
| Biochemistry, Genetics and Molecular Biology | 73 | 19% |
| Medicine and Dentistry | 35 | 9% |
| Chemistry | 33 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 34 | 9% |
| Unknown | 73 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2023.
All research outputs
#3,786,983
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#736
of 4,151 outputs
Outputs of similar age
#12,627
of 82,540 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 39 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.