Title |
Incidence of Menkes disease
|
---|---|
Published in |
Human Genetics, February 1991
|
DOI | 10.1007/bf00201846 |
Pubmed ID | |
Authors |
T. Tønnesen, W. J. Kleijer, N. Horn |
Abstract |
We have calculated the incidence of Menkes disease for Denmark, France, The Netherlands, the United Kingdom and West Germany, based on known Menkes patients born during the time period 1976-87. Considering live-born Menkes patients, the combined incidence for these five countries is 1 Menkes patient per 298,000 live-born babies. If the number of affected aborted fetuses are taken into account, the incidence is 1 Menkes per 254,000 live-born babies. This incidence, which is 2-4 times lower than earlier published incidence figures, places Menkes disease as an extremely rare disease. The mutation rate for Menkes disease is estimated to be 1.96 x 10(-6), based on the number of isolated Menkes cases born during the time period 1976-87 and the total number of newborn males during this time. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 22% |
Student > Bachelor | 4 | 15% |
Student > Master | 3 | 11% |
Professor | 2 | 7% |
Student > Doctoral Student | 1 | 4% |
Other | 5 | 19% |
Unknown | 6 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 15% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Agricultural and Biological Sciences | 4 | 15% |
Nursing and Health Professions | 1 | 4% |
Unspecified | 1 | 4% |
Other | 5 | 19% |
Unknown | 8 | 30% |