| Title |
Menkes Copper-Translocating P-type ATPase (ATP7A): Biochemical and Cell Biology Properties, and Role in Menkes Disease
|
|---|---|
| Published in |
Journal of Bioenergetics and Biomembranes, October 2002
|
| DOI | 10.1023/a:1021250003104 |
| Pubmed ID | |
| Authors |
Ilia Voskoboinik, James Camakaris |
| Abstract |
The Menkes copper-translocating P-type ATPase (ATP7A; MNK) is a ubiquitous protein that regulates the absorption of copper in the gastrointestinal tract. Inside cells the protein has a dual function: it delivers copper to cuproenzymes in the Golgi compartment and effluxes excess copper. The latter property is achieved through copper-dependent vesicular trafficking of the Menkes protein to the plasma membrane of the cell. The trafficking mechanism and catalytic activity combine to facilitate absorption and intercellular transport of copper. The mechanism of catalysis and copper-dependent trafficking of the Menkes protein are the subjects of this review. Menkes disease, a systemic copper deficiency disorder, is caused by mutations in the gene encoding the Menkes protein. The effect of these mutations on the catalytic cycle and the cell biology of the Menkes protein, as well as predictions of the effect of particular mutant MNKs on observed Menkes disease symptoms will also be discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Australia | 2 | 4% |
| Unknown | 47 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 18% |
| Student > Ph. D. Student | 9 | 18% |
| Researcher | 7 | 14% |
| Professor > Associate Professor | 6 | 12% |
| Student > Doctoral Student | 5 | 10% |
| Other | 9 | 18% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 33% |
| Chemistry | 9 | 18% |
| Biochemistry, Genetics and Molecular Biology | 9 | 18% |
| Medicine and Dentistry | 3 | 6% |
| Environmental Science | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 9 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2016.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Journal of Bioenergetics and Biomembranes
#115
of 491 outputs
Outputs of similar age
#17,268
of 49,678 outputs
Outputs of similar age from Journal of Bioenergetics and Biomembranes
#1
of 4 outputs
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So far Altmetric has tracked 491 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
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