| Title |
The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer
|
|---|---|
| Published in |
Journal of neural transmission, June 1992
|
| DOI | 10.1007/bf01244820 |
| Pubmed ID | |
| Authors |
J. Hyttel, K. P. Bøgesø, J. Perregaard, C. Sánchez |
| Abstract |
The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers*) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Denmark | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 70 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 18% |
| Student > Bachelor | 12 | 16% |
| Student > Master | 10 | 14% |
| Researcher | 8 | 11% |
| Professor | 4 | 5% |
| Other | 10 | 14% |
| Unknown | 16 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 19 | 26% |
| Medicine and Dentistry | 9 | 12% |
| Agricultural and Biological Sciences | 9 | 12% |
| Neuroscience | 6 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 11 | 15% |
| Unknown | 16 | 22% |