| Title |
Structure and function of Zika virus NS5 protein: perspectives for drug design
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, February 2018
|
| DOI | 10.1007/s00018-018-2751-x |
| Pubmed ID | |
| Authors |
Boxiao Wang, Stephanie Thurmond, Rong Hai, Jikui Song |
| Abstract |
Zika virus (ZIKV) belongs to the positive-sense single-stranded RNA-containing Flaviviridae family. Its recent outbreak and association with human diseases (e.g. neurological disorders) have raised global health concerns, and an urgency to develop a therapeutic strategy against ZIKV infection. However, there is no currently approved antiviral against ZIKV. Here we present a comprehensive overview on recent progress in structure-function investigation of ZIKV NS5 protein, the largest non-structural protein of ZIKV, which is responsible for replication of the viral genome, RNA capping and suppression of host interferon responses. Structural comparison of the N-terminal methyltransferase domain and C-terminal RNA-dependent RNA polymerase domain of ZIKV NS5 with their counterparts from related viruses provides mechanistic insights into ZIKV NS5-mediated RNA replication, and identifies residues critical for its enzymatic activities. Finally, a collection of recently identified small molecule inhibitors against ZIKV NS5 or its closely related flavivirus homologues are also discussed. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 150 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 16% |
| Student > Bachelor | 23 | 15% |
| Researcher | 13 | 9% |
| Student > Master | 13 | 9% |
| Student > Doctoral Student | 12 | 8% |
| Other | 19 | 13% |
| Unknown | 46 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 30 | 20% |
| Immunology and Microbiology | 18 | 12% |
| Agricultural and Biological Sciences | 15 | 10% |
| Chemistry | 12 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Other | 14 | 9% |
| Unknown | 52 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2018.
All research outputs
#19,201,293
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,458
of 4,151 outputs
Outputs of similar age
#333,916
of 442,989 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#41
of 55 outputs
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.