| Title |
Kappa opioid antagonists: Past successes and future prospects
|
|---|---|
| Published in |
The AAPS Journal, October 2005
|
| DOI | 10.1208/aapsj070371 |
| Pubmed ID | |
| Authors |
Matthew D. Metcalf, Andrew Coop |
| Abstract |
Antagonists of the kappa opioid receptor were initially investigated as pharmacological tools that would reverse the effects of kappa opioid receptor agonists. In the years following the discovery of the first selective kappa opioid antagonists, much information about their chemistry and pharmacology has been elicited and their potential therapeutic uses have been investigated. The review presents the current chemistry, ligand-based structure activity relationships, and pharmacology of the known nonpeptidic selective kappa opioid receptor antagonists. This manuscript endeavors to provide the reader with a useful reference of the investigations made to define the structure-activity relationships and pharmacology of selective kappa opioid receptor antagonists and their potential uses as pharmacological tools and as therapeutic agents in the treatment of disease states. |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 2 | 1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 130 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 8% |
| Student > Ph. D. Student | 7 | 5% |
| Student > Bachelor | 3 | 2% |
| Professor | 3 | 2% |
| Other | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 101 | 75% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 7% |
| Chemistry | 7 | 5% |
| Agricultural and Biological Sciences | 6 | 4% |
| Psychology | 4 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 5 | 4% |
| Unknown | 101 | 75% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2022.
All research outputs
#5,446,994
of 25,374,647 outputs
Outputs from The AAPS Journal
#283
of 1,463 outputs
Outputs of similar age
#13,725
of 75,088 outputs
Outputs of similar age from The AAPS Journal
#5
of 25 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,463 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,088 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.