| Title |
Usefulness of permutation entropy as an anesthetic depth indicator in children
|
|---|---|
| Published in |
Journal of Pharmacokinetics and Pharmacodynamics, February 2015
|
| DOI | 10.1007/s10928-015-9405-5 |
| Pubmed ID | |
| Authors |
Pil-Jong Kim, Hong-Gee Kim, Gyu-Jeong Noh, Yong-Seo Koo, Teo Jeon Shin |
| Abstract |
Permutation entropy (PE) as a complexity measure has been introduced to monitor anesthetic depth for adult. However, PE has not yet been evaluated for its clinical applicability as an indicator of anesthetic depth in children. Therefore, in order to investigate the validity of PE, we compared PE with BIS using pharmacodynamic (PD) modeling in children. Electroencephalogram (EEG) was obtained from BIS monitor during sevoflurane deepening and lightening protocol. End-tidal sevoflurane concentration (Etsevo) and BIS were measured simultaneously. PE was calculated from the processed EEG with the scale ranging from 0 to 100. NONMEM software was used to investigate the PD relationship between Etsevo with BIS and PE. Adjusted PE (APE) values were decreased as anesthesia deepened. APE and BIS showed significant linear correlation (P < 0.001), indicating that PE also reflects anesthesia depth. PD parameters for APE and BIS were estimated with a sigmoid Emax model which describes the relationship between Etsevo and APE/BIS (E o : 78, E max : 17.6, C e50 : 2.5 vol%; γ: 13.1, k eo : 0.47 min(-1) for APE; E o : 89.4; E max : 15.7; C e50 : 2.2 vol%; γ: 6.6, keo: 0.52 min(-1) for BIS). PE seems to be a useful indicator of anesthetic depth, which is comparable to BIS in children. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 16% |
| Researcher | 5 | 16% |
| Student > Master | 3 | 9% |
| Other | 2 | 6% |
| Student > Bachelor | 1 | 3% |
| Other | 5 | 16% |
| Unknown | 11 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 25% |
| Engineering | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Other | 5 | 16% |
| Unknown | 10 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2015.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Journal of Pharmacokinetics and Pharmacodynamics
#328
of 477 outputs
Outputs of similar age
#221,770
of 360,574 outputs
Outputs of similar age from Journal of Pharmacokinetics and Pharmacodynamics
#1
of 3 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 477 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,574 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them