| Title |
The ABC transporter structure and mechanism: perspectives on recent research
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, March 2004
|
| DOI | 10.1007/s00018-003-3336-9 |
| Pubmed ID | |
| Authors |
P. M. Jones, A. M. George |
| Abstract |
ATP-binding cassette (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic microbes to drugs. Elucidation of the structure and mechanism of ABC transporters is essential to the rational design of agents to control their function. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the protein's mechanism remain unanswered. In this review, we examine the recent structural data concerning ABC transporters and related proteins in the light of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters' molecular mechanism. |
Mendeley readers
The data shown below were compiled from readership statistics for 456 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| United Kingdom | 3 | <1% |
| South Africa | 2 | <1% |
| France | 1 | <1% |
| India | 1 | <1% |
| Canada | 1 | <1% |
| Portugal | 1 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 440 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 105 | 23% |
| Student > Master | 79 | 17% |
| Student > Bachelor | 74 | 16% |
| Researcher | 50 | 11% |
| Student > Doctoral Student | 21 | 5% |
| Other | 50 | 11% |
| Unknown | 77 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 162 | 36% |
| Biochemistry, Genetics and Molecular Biology | 95 | 21% |
| Medicine and Dentistry | 30 | 7% |
| Chemistry | 27 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 20 | 4% |
| Other | 38 | 8% |
| Unknown | 84 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2021.
All research outputs
#3,212,897
of 26,017,215 outputs
Outputs from Cellular and Molecular Life Sciences
#529
of 6,041 outputs
Outputs of similar age
#5,662
of 65,310 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#3
of 25 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,041 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 65,310 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.