| Title |
Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, October 2008
|
| DOI | 10.1007/s00259-008-0960-5 |
| Pubmed ID | |
| Authors |
Adrianus J. de Langen, Bianca Klabbers, Mark Lubberink, Ronald Boellaard, Marieke D. Spreeuwenberg, Ben J. Slotman, Remco de Bree, Egbert F. Smit, Otto S. Hoekstra, Adriaan A. Lammertsma |
| Abstract |
Positron emission tomography (PET) using (18)F-3'-deoxy-3'-fluorothymidine ([(18)F]FLT) allows noninvasive monitoring of tumour proliferation. For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [(18)F]FLT measurements. Nine patients with non-small-cell lung cancer (NSCLC) and six with head-and-neck cancer (HNC) underwent [(18)F]FLT PET twice within 7 days prior to therapy. The maximum pixel value (SUV(max)) and a threshold defined volume (SUV(41%)) were defined for all delineated lesions. The plasma to tumour transfer constant (K(i)) was estimated using both Patlak graphical analysis and nonlinear regression (NLR). NLR was also used to estimate k(3), which, at least in theory, selectively reflects thymidine kinase 1 activity. The level of agreement between test and retest values was assessed using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. All primary tumours and >90% of clinically suspected locoregional metastases could be delineated. In total, 24 lesions were defined. NLR-derived K(i), Patlak-derived K(i), SUV(41%) and SUV(max) showed excellent reproducibility with ICCs of 0.92, 0.95, 0.98 and 0.93, and SDs of 16%, 12%, 7% and 11%, respectively. Reproducibility was poor for k(3) with an ICC of 0.43 and SD of 38%. Quantitative [(18)F]FLT measurements are reproducible in both NSCLC and HNC patients. When monitoring response in individual patients, changes of more than 15% in SUV(41%), 20-25% in SUV(max) and Patlak-derived K(i), and 32% in NLR3k-derived K(i) are likely to represent treatment effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 3% |
| Germany | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 34 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 27% |
| Student > Ph. D. Student | 8 | 22% |
| Professor | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Student > Doctoral Student | 2 | 5% |
| Other | 7 | 19% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 57% |
| Agricultural and Biological Sciences | 4 | 11% |
| Physics and Astronomy | 4 | 11% |
| Computer Science | 2 | 5% |
| Neuroscience | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 4 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2022.
All research outputs
#7,850,857
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#981
of 3,083 outputs
Outputs of similar age
#33,203
of 92,683 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#2
of 14 outputs
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