| Title |
Albuminuria, serum creatinine, and estimated glomerular filtration rate as predictors of cardio-renal outcomes in patients with type 2 diabetes mellitus and kidney disease: a systematic literature review
|
|---|---|
| Published in |
BMC Nephrology, February 2018
|
| DOI | 10.1186/s12882-018-0821-9 |
| Pubmed ID | |
| Authors |
Keith C. Norris, Karen E. Smoyer, Catherine Rolland, Jan Van der Vaart, Eliza Beth Grubb |
| Abstract |
Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid represent independent predictors of kidney disease progression or subsequent outcomes among individuals with type 2 diabetes mellitus (T2DM). This study systematically examined the available literature documenting the role of albuminuria, serum creatinine, eGFR, and uric acid in predicting kidney disease progression and cardio-renal outcomes in persons with T2DM. Embase, MEDLINE, and Cochrane Central Trials Register and Database of Systematic Reviews were searched for relevant studies from January 2000 through May 2016. PubMed was searched from 2013 until May 2016 to retrieve studies not yet indexed in the other databases. Observational cohort or non-randomized longitudinal studies relevant to albuminuria, serum creatinine, eGFR, uric acid and their association with kidney disease progression, non-fatal cardiovascular events, and all-cause mortality as outcomes in persons with T2DM, were eligible for inclusion. Two reviewers screened citations to ensure studies met inclusion criteria. From 2249 citations screened, 81 studies were retained, of which 39 were omitted during the extraction phase (cross-sectional [n = 16]; no outcome/measure of interest [n = 13]; not T2DM specific [n = 7]; review article [n = 1]; editorial [n = 1]; not in English language [n = 1]). Of the remaining 42 longitudinal study publications, biomarker measurements were diverse, with seven different measures for eGFR and five different measures for albuminuria documented. Kidney disease progression differed substantially across 31 publications, with GFR loss (n = 9 [29.0%]) and doubling of serum creatinine (n = 5 [16.1%]) the most frequently reported outcome measures. Numerous publications presented risk estimates for albuminuria (n = 18), serum creatinine/eGFR (n = 13), or both combined (n = 6), with only one study reporting for uric acid. Most often, these biomarkers were associated with a greater risk of experiencing clinical outcomes. Despite the utility of albuminuria, serum creatinine, and eGFR as predictors of kidney disease progression, further efforts to harmonize biomarker measurements are needed given the disparate methodologies observed in this review. Such efforts would help better establish the clinical significance of these and other biomarkers of renal function and cardio-renal outcomes in persons with T2DM. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 9 | 56% |
| United States | 1 | 6% |
| France | 1 | 6% |
| Peru | 1 | 6% |
| Unknown | 4 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 56% |
| Practitioners (doctors, other healthcare professionals) | 6 | 38% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 150 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 11% |
| Student > Ph. D. Student | 16 | 11% |
| Student > Bachelor | 11 | 7% |
| Student > Postgraduate | 7 | 5% |
| Researcher | 7 | 5% |
| Other | 24 | 16% |
| Unknown | 69 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 20% |
| Biochemistry, Genetics and Molecular Biology | 12 | 8% |
| Immunology and Microbiology | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Nursing and Health Professions | 5 | 3% |
| Other | 18 | 12% |
| Unknown | 72 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2018.
All research outputs
#3,181,360
of 23,573,233 outputs
Outputs from BMC Nephrology
#310
of 2,539 outputs
Outputs of similar age
#74,733
of 444,897 outputs
Outputs of similar age from BMC Nephrology
#10
of 48 outputs
Altmetric has tracked 23,573,233 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,539 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.