| Title |
Effect of In Ovo Zinc Injection on the Embryonic Development and Epigenetics-Related Indices of Zinc-Deprived Broiler Breeder Eggs
|
|---|---|
| Published in |
Biological Trace Element Research, February 2018
|
| DOI | 10.1007/s12011-018-1260-y |
| Pubmed ID | |
| Authors |
Xiaoming Sun, Lin Lu, Xiudong Liao, Liyang Zhang, Xi Lin, Xugang Luo, Qiugang Ma |
| Abstract |
The role of in ovo zinc (Zn) injection in improving the embryonic development in eggs from Zn-deficient hens, via epigenetic and antioxidant mechanisms, was examined. A completely randomized design involving a 1 (the non-injected control) + 1 (the injected control with sterilized water) + 2 (Zn source) × 2 (Zn level) factorial arrangement of treatments was used. The two injected Zn sources were inorganic Zn sulfate and organic Zn-lysine chelate with a moderate chelation strength, and the two injected Zn levels were 50 and 100 μg Zn/egg. In ovo Zn injection decreased (P < 0.05) embryonic mortality, and increased (P < 0.05) hatchability and healthy chick ratio. In ovo Zn injection increased (P < 0.05) embryonic tibia Zn content, but had no effect (P > 0.05) on copper (Cu)- and Zn-containing superoxide dismutase (CuZnSOD) activities and metallothionein IV (MT4) levels or their mRNA expression levels and malondialdehyde (MDA) levels in the embryonic liver. In ovo Zn injection had no effect (P > 0.05) on the global level of DNA methylation or DNA methylation and histone 3 lysine 9 (H3K9) acetylation levels of the MT4 promoter in the embryonic liver. However, the organic Zn had higher (P < 0.05) levels of DNA methylation and H3K9 acetylation than inorganic Zn. These data demonstrate that in ovo Zn injection improved the embryonic development, and the organic Zn was more effective than inorganic Zn in enhancing DNA methylation and H3K9 acetylation in the liver MT4 promoter, but the precise mechanisms require further investigations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 13% |
| Student > Master | 3 | 13% |
| Other | 2 | 8% |
| Professor | 2 | 8% |
| Lecturer | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 10 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 38% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 11 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2018.
All research outputs
#20,465,050
of 23,023,224 outputs
Outputs from Biological Trace Element Research
#1,590
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Outputs of similar age
#380,147
of 442,600 outputs
Outputs of similar age from Biological Trace Element Research
#20
of 23 outputs
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