| Title |
Calorie restriction and the nutrient sensing signaling pathways
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, January 2007
|
| DOI | 10.1007/s00018-007-6381-y |
| Pubmed ID | |
| Authors |
I. Dilova, E. Easlon, S. -J. Lin |
| Abstract |
Calorie restriction (CR) is the most potent regimen known to extend the life span in multiple species. CR has also been shown to ameliorate several age-associated disorders in mammals and perhaps humans. CR induces diverse metabolic changes in organisms, and it is currently unclear whether and how these metabolic changes lead to life span extension. Recent studies in model systems have provided insight into the molecular mechanisms by which CR extends life span. In this review, we summarize and provide recent updates on multiple nutrient signaling pathways that have been connected to CR and longevity regulation. The roles of highly conserved longevity regulators--the Sirtuin family--in CR are also discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 5% |
| Netherlands | 2 | 2% |
| India | 1 | <1% |
| Austria | 1 | <1% |
| Singapore | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 105 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 22% |
| Researcher | 20 | 17% |
| Student > Master | 16 | 14% |
| Student > Bachelor | 13 | 11% |
| Professor > Associate Professor | 10 | 9% |
| Other | 17 | 15% |
| Unknown | 15 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 50% |
| Biochemistry, Genetics and Molecular Biology | 21 | 18% |
| Medicine and Dentistry | 13 | 11% |
| Neuroscience | 4 | 3% |
| Nursing and Health Professions | 1 | <1% |
| Other | 2 | 2% |
| Unknown | 18 | 15% |