Title |
Human gastrin-releasing peptide gene maps to chromosome band 18q21
|
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Published in |
Somatic Cell and Molecular Genetics, January 1987
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DOI | 10.1007/bf02422302 |
Pubmed ID | |
Authors |
Anne -Marie Lebacq-Verheyden, Virginia Bertness, Ilan Kirsch, Gregory F. Hollis, O. Wesley McBride, James Battey |
Abstract |
A complementary DNA clone encoding human pre-pro gastrin-releasing peptide, a 27-amino acid neuropeptide and putative growth factor, was used to determine the chromosomal location of this gene. Southern blot hybridization to genomic DNA isolated from a panel of human-rodent somatic cell hybrids unambiguously maps this gene to human chromosome 18. In situ chromosomal hybridization confirms the hybrid data and further localized the gene to chromosome band 18q21. Karyotypic abnormalities in tumors and inherited disease states which involve chromosome band 18q21 may now be studied for correlated changes in the structure and expression of the human GRP gene. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor > Associate Professor | 1 | 50% |
Student > Doctoral Student | 1 | 50% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 50% |
Agricultural and Biological Sciences | 1 | 50% |