| Title |
Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery
|
|---|---|
| Published in |
AAPS PharmSciTech, December 2012
|
| DOI | 10.1208/s12249-012-9888-y |
| Pubmed ID | |
| Authors |
Thiagarajan Madheswaran, Rengarajan Baskaran, Raj Kumar Thapa, Jeong Yeon Rhyu, Hye Yoon Choi, Jong Oh Kim, Chul Soon Yong, Bong Kyu Yoo |
| Abstract |
In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro release, and skin permeation-retention properties. The particle size ranged from 153.8 to 170.2 nm with a cubical shape and exhibited controlled release profile with less than 20% of the drug released in the first 24 h. The release profile was significantly altered with addition of different additives. Formulation with lower monoolein exhibited higher skin permeation with a flux rate of 0.061±0.005 μg cm(-2) h(-1) in 24 h. The permeation however, significantly increased with glycerol, propylene glycol, and polyethylene glycol 400, while it declined for the addition of oleic acid. A similar trend was observed with skin retention study. In conclusion, FNS-loaded LCN could be advocated as a viable alternative for oral administration of the drug. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 85 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 18% |
| Student > Master | 14 | 16% |
| Student > Ph. D. Student | 10 | 12% |
| Researcher | 9 | 11% |
| Student > Doctoral Student | 4 | 5% |
| Other | 8 | 9% |
| Unknown | 25 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 30 | 35% |
| Medicine and Dentistry | 9 | 11% |
| Chemistry | 7 | 8% |
| Materials Science | 4 | 5% |
| Agricultural and Biological Sciences | 2 | 2% |
| Other | 3 | 4% |
| Unknown | 30 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2018.
All research outputs
#7,208,880
of 22,785,242 outputs
Outputs from AAPS PharmSciTech
#422
of 1,468 outputs
Outputs of similar age
#78,591
of 278,100 outputs
Outputs of similar age from AAPS PharmSciTech
#11
of 22 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,468 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,100 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.