| Title |
Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, January 2018
|
| DOI | 10.1007/s00210-018-1466-8 |
| Pubmed ID | |
| Authors |
Sara A. Khedr, Ahmed A. Elmelgy, Omnyah A. El-Kharashi, Hadwa A. Abd-Alkhalek, Manal L. Louka, Hoda A. Sallam, Sawsan Aboul-Fotouh |
| Abstract |
Several hypotheses link high fat diet (HFD) with the pathophysiology of depression and its response to antidepressants. This study aimed to determine the effect of metformin (MET) on the cognitive and antidepressant activity of fluoxetine (FLU) through its effect on c-Jun expression. Behavioral, cognitive function, biochemical, and histopathological studies were performed in non-HFD- and HFD-fed rats exposed to chronic restraint stress (CRS). Stressed group showed cognitive impairment, depressive-like symptoms, disturbed glucose homeostasis and lipid profile, reduced adiponectin level, brain-derived neurotrophic factor (BDNF) expression, and increased corticosterone and c-Jun. All these were aggravated by HFD. MET, FLU and their combination produced significant improvement in lipid profile with significant increase in adiponectin and BDNF expression. Corticosterone, body weight and insulin resistance showed significant decrease in the treated groups. Moreover, there was a significant decrease in hippocampal c Jun expression. There was a significant preferable effect toward the combination. Conclusion, MET may decrease the refractoriness to FLU and improves the cognition in individuals who are fed on HFD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Puerto Rico | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 81 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 16% |
| Student > Master | 8 | 10% |
| Student > Ph. D. Student | 7 | 9% |
| Researcher | 6 | 7% |
| Student > Doctoral Student | 5 | 6% |
| Other | 16 | 20% |
| Unknown | 26 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 14% |
| Agricultural and Biological Sciences | 7 | 9% |
| Neuroscience | 7 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 7% |
| Psychology | 5 | 6% |
| Other | 14 | 17% |
| Unknown | 31 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2018.
All research outputs
#15,492,327
of 23,023,224 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#1,364
of 1,748 outputs
Outputs of similar age
#270,489
of 441,607 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#7
of 19 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,748 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,607 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.