| Title |
Targeting the Microbiota, From Irritable Bowel Syndrome to Mood Disorders: Focus on Probiotics and Prebiotics
|
|---|---|
| Published in |
Current Pathobiology Reports, February 2018
|
| DOI | 10.1007/s40139-018-0160-3 |
| Pubmed ID | |
| Authors |
Matteo M. Pusceddu, Kaitlin Murray, Melanie G. Gareau |
| Abstract |
The crosstalk between the gut and the brain has revealed a complex communication system responsible for maintaining a proper gastrointestinal homeostasis as well as affect emotional mood and cognitive functions. Recent research has revealed that beneficial manipulation of the microbiota by probiotics and prebiotics represent an emerging and novel strategy for the treatment of a large spectrum of diseases ranging from visceral pain to mood disorders. The review critically evaluates current knowledge of the effects exerted by both probiotics and prebiotics in irritable bowel syndrome (IBS) and mood disorders such as anxiety and depression. Relevant literature was identified through a search of MEDLINE via PubMed using the following words, "probiotics", "prebiotics", "microbiota", and "gut-brain axis" in combination with "stress", "depression", "IBS", and "anxiety". A number of trials have shown efficacy of probiotics and prebiotics in ameliorating both IBS related symptoms and emotional states. However, limitations have been found especially due to the small number of clinical studies, studies design, patient sample size, and placebo effect. Nonetheless, current finding supports the view that beneficial manipulation of the microbiota through both probiotics and prebiotics intake represents a novel attractive strategy to treat gut-brain axis disorders such as IBS and depression. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 40% |
| Spain | 2 | 20% |
| Switzerland | 1 | 10% |
| Australia | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Scientists | 3 | 30% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 131 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 15% |
| Student > Master | 17 | 13% |
| Researcher | 12 | 9% |
| Student > Ph. D. Student | 8 | 6% |
| Student > Doctoral Student | 8 | 6% |
| Other | 27 | 21% |
| Unknown | 39 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 14% |
| Biochemistry, Genetics and Molecular Biology | 13 | 10% |
| Agricultural and Biological Sciences | 10 | 8% |
| Nursing and Health Professions | 9 | 7% |
| Psychology | 7 | 5% |
| Other | 30 | 23% |
| Unknown | 44 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2023.
All research outputs
#2,115,347
of 24,294,767 outputs
Outputs from Current Pathobiology Reports
#3
of 110 outputs
Outputs of similar age
#51,213
of 452,850 outputs
Outputs of similar age from Current Pathobiology Reports
#1
of 6 outputs
Altmetric has tracked 24,294,767 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 110 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them