| Title |
Signaling Pathways in Cancer and Embryonic Stem Cells
|
|---|---|
| Published in |
Stem Cell Reviews and Reports, May 2007
|
| DOI | 10.1007/s12015-007-0004-8 |
| Pubmed ID | |
| Authors |
Oliver Dreesen, Ali H. Brivanlou |
| Abstract |
Cancer cells have the ability to divide indefinitely and spread to different parts of the body during metastasis. Embryonic stem cells can self-renew and, through differentiation to somatic cells, provide the building blocks of the human body. Embryonic stem cells offer tremendous opportunities for regenerative medicine and serve as an excellent model system to study early human development. Many of the molecular mechanism underlying tumorigenesis in cancer and self-renewal in stem cells have been elucidated in the past decade. Here we present a systematic analysis of seven major signaling pathways implicated in both cancer and stem cells. We present on overview of the JAK/STAT, Notch, MAPK/ERK, PI3K/AKT, NF-kB, Wnt and TGF-beta pathways and analyze their activation status in the context of cancer and stem cells. We focus on their role in stem cell self-renewal and development and identify key molecules, whose aberrant expression has been associated with malignant phenotypes. We conclude by presenting a map of the signaling networks involved in cancer and embryonic stem cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 425 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 4 | <1% |
| United States | 4 | <1% |
| India | 4 | <1% |
| Japan | 2 | <1% |
| United Kingdom | 2 | <1% |
| South Africa | 2 | <1% |
| Malaysia | 1 | <1% |
| Hungary | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 5 | 1% |
| Unknown | 399 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 98 | 23% |
| Researcher | 71 | 17% |
| Student > Master | 53 | 12% |
| Student > Bachelor | 48 | 11% |
| Student > Doctoral Student | 22 | 5% |
| Other | 68 | 16% |
| Unknown | 65 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 190 | 45% |
| Biochemistry, Genetics and Molecular Biology | 75 | 18% |
| Medicine and Dentistry | 36 | 8% |
| Engineering | 13 | 3% |
| Chemistry | 9 | 2% |
| Other | 28 | 7% |
| Unknown | 74 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 March 2024.
All research outputs
#3,798,611
of 25,374,647 outputs
Outputs from Stem Cell Reviews and Reports
#119
of 1,036 outputs
Outputs of similar age
#9,702
of 83,093 outputs
Outputs of similar age from Stem Cell Reviews and Reports
#3
of 9 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,036 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,093 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.