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The anti-mutagenic properties of bile pigments

Overview of attention for article published in Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, May 2007
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

blogs
1 blog
patent
1 patent
wikipedia
5 Wikipedia pages

Citations

dimensions_citation
62 Dimensions

Readers on

mendeley
60 Mendeley
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Title
The anti-mutagenic properties of bile pigments
Published in
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, May 2007
DOI 10.1016/j.mrrev.2007.05.001
Pubmed ID
Authors

A.C. Bulmer, K. Ried, J.T. Blanchfield, K.-H. Wagner

Abstract

Bile pigments, including bilirubin and biliverdin, are endogenous compounds belonging to the porphyrin family of molecules. In the past, bile pigments and bilirubin in particular were thought of as useless by-products of heme catabolism that can be toxic if they accumulate. However, in the past 20 years, research probing the physiological relevance of bile pigments has been mounting, with evidence to suggest bile pigments possess significant antioxidant and anti-mutagenic properties. More specifically, bile pigments are potent peroxyl radical scavengers and inhibit the mutagenic effects of a number of classes of mutagens (polycyclic aromatic hydrocarbons, heterocyclic amines, oxidants). Coincidentally, persons with elevated circulating bilirubin concentrations have a reduced prevalence of cancer and cardio-vascular disease. Despite the encouraging in vitro anti-mutagenic effects of bile pigments, relatively little research has been conducted on their inhibitory capacity in bacterial and cultured cell assays of mutation, which might link the existing in vitro and in vivo observations. This is the first review to summarise the published data and it is our hope it will stimulate further research on these potentially preventative compounds.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
United States 1 2%
India 1 2%
Unknown 57 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 17%
Student > Ph. D. Student 9 15%
Researcher 8 13%
Student > Bachelor 6 10%
Lecturer > Senior Lecturer 3 5%
Other 12 20%
Unknown 12 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 35%
Medicine and Dentistry 6 10%
Chemistry 5 8%
Biochemistry, Genetics and Molecular Biology 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 7 12%
Unknown 14 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2021.
All research outputs
#3,121,755
of 25,374,917 outputs
Outputs from Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
#325
of 5,283 outputs
Outputs of similar age
#7,985
of 84,362 outputs
Outputs of similar age from Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
#2
of 20 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,283 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,362 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.