| Title |
Vesicular monoamine transporter 2: Role as a novel target for drug development
|
|---|---|
| Published in |
The AAPS Journal, November 2006
|
| DOI | 10.1208/aapsj080478 |
| Pubmed ID | |
| Authors |
Guangrong Zheng, Linda P. Dwoskin, Peter A. Crooks |
| Abstract |
In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is the only transporter that moves cytoplasmic dopamine (DA) into synaptic vesicles for storage and subsequent exocytotic release. Pharmacologically enhancing DA sequestration by VMAT2, and thus preventing the oxidation of DA in the cytoplasm, may be a strategy for treating diseases such as Parkinson's disease. VMAT2 may also be a novel target for the development of treatments for psychostimulant abuse. This review summarizes the possible role of VMAT2 as a therapeutic target, VMAT2 ligands reported in the literature, and the structure-activity relationship of these ligands, including tetrabenazine analogs, ketanserin analogs, lobeline analogs, and 3-amine-2-phenylpropene analogs. The molecular structure of VMAT2 and its relevance to ligand binding are briefly discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Spain | 1 | 1% |
| New Zealand | 1 | 1% |
| Unknown | 76 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 19% |
| Student > Ph. D. Student | 15 | 19% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 9 | 11% |
| Professor > Associate Professor | 6 | 7% |
| Other | 15 | 19% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 35% |
| Medicine and Dentistry | 10 | 12% |
| Chemistry | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Neuroscience | 7 | 9% |
| Other | 8 | 10% |
| Unknown | 13 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2019.
All research outputs
#3,798,945
of 25,374,917 outputs
Outputs from The AAPS Journal
#181
of 1,463 outputs
Outputs of similar age
#9,256
of 87,973 outputs
Outputs of similar age from The AAPS Journal
#2
of 4 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,463 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 87,973 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.