| Title |
Gene regulation and large-scale chromatin organization in the nucleus
|
|---|---|
| Published in |
Chromosome Research, March 2006
|
| DOI | 10.1007/s10577-006-1027-8 |
| Pubmed ID | |
| Authors |
Niall Dillon |
| Abstract |
Regulation of gene expression involves a number of different levels of organization in the cell nucleus. The main agents of transcriptional control are the cis-acting sequences in the immediate vicinity of a gene, which combine to form the functional unit or domain. Contacts between these sequences through the formation of chromatin loops forms the most basic level of organization. The activity of functional domains is also influenced by higher order chromatin structures that impede or permit access of factors to the genes. Epigenetic modifications can maintain and propagate these active or repressive chromatin structures across large genomic regions or even entire chromosomes. There is also evidence that transcription is organized into structures called 'factories' and that this can lead to inter-chromosomal contacts between genes that have the potential to influence their regulation. |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| United Kingdom | 3 | 3% |
| Germany | 2 | 2% |
| Pakistan | 1 | 1% |
| Spain | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 85 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 22% |
| Student > Bachelor | 20 | 21% |
| Student > Ph. D. Student | 15 | 16% |
| Student > Master | 8 | 8% |
| Professor | 6 | 6% |
| Other | 12 | 13% |
| Unknown | 14 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 46% |
| Biochemistry, Genetics and Molecular Biology | 17 | 18% |
| Medicine and Dentistry | 9 | 9% |
| Computer Science | 3 | 3% |
| Arts and Humanities | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 16 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2021.
All research outputs
#7,453,126
of 22,785,242 outputs
Outputs from Chromosome Research
#145
of 507 outputs
Outputs of similar age
#24,502
of 71,288 outputs
Outputs of similar age from Chromosome Research
#3
of 6 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 507 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,288 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.