Title |
α‐Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes
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Published in |
FEBS Journal, June 2004
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DOI | 10.1111/j.1432-1033.2004.04145.x |
Pubmed ID | |
Authors |
Annette Nicke, Susan Wonnacott, Richard J. Lewis |
Abstract |
Cone snails comprise approximately 500 species of venomous molluscs, which have evolved the ability to generate multiple toxins with varied and often exquisite selectivity. One class, the alpha-conotoxins, is proving to be a powerful tool for the differentiation of nicotinic acetylcholine receptors (nAChRs). These comprise a large family of complex subtypes, whose significance in physiological functions and pathological conditions is increasingly becoming apparent. After a short introduction into the structure and diversity of nAChRs, this overview summarizes the identification and characterization of alpha-conotoxins with selectivity for neuronal nAChR subtypes and provides examples of their use in defining the compositions and function of neuronal nAChR subtypes in native vertebrate tissues. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
United States | 2 | 2% |
Germany | 2 | 2% |
Australia | 1 | 1% |
Unknown | 75 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 20% |
Student > Master | 16 | 20% |
Student > Bachelor | 12 | 15% |
Researcher | 7 | 9% |
Professor | 5 | 6% |
Other | 12 | 15% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 24 | 29% |
Biochemistry, Genetics and Molecular Biology | 15 | 18% |
Neuroscience | 8 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
Chemistry | 6 | 7% |
Other | 10 | 12% |
Unknown | 12 | 15% |