| Title |
Selective Serotonin Reuptake Inhibitors (SSRIs) and Markers of Bone Turnover in Men
|
|---|---|
| Published in |
Calcified Tissue International, February 2018
|
| DOI | 10.1007/s00223-018-0398-0 |
| Pubmed ID | |
| Authors |
Lana J. Williams, Michael Berk, Jason M. Hodge, Mark A. Kotowicz, Amanda L. Stuart, Vinoomika Chandrasekaran, Jasmine Cleminson, Julie A. Pasco |
| Abstract |
Selective serotonin reuptake inhibitors (SSRIs) have been shown to have a clinically significant impact on bone metabolism. To explore this further, we aimed to determine whether these agents are associated with serum markers of bone turnover utilising a population-based sample of men (n = 1138; 20-96 year) participating in the Geelong Osteoporosis Study. Blood samples were obtained and the bone resorption marker, C-telopeptide (CTx) and formation marker, type 1 procollagen amino-terminal-propeptide (PINP) were measured. Anthropometry and socio-economic status (SES) were determined and information on medication use and lifestyle was obtained via questionnaire. Lifetime mood disorders were assessed using semi-structured clinical interviews. Thirty-seven (3.3%) men reported using SSRIs. Age was an effect modifier in the association between SSRIs and markers of bone turnover. Among younger men (20-60 year; n = 557), adjusted mean CTx and PINP values were 12.4% [16.7 (95% CI 14.6-18.8) vs 19.1 (95% CI 18.7-19.4) pg/ml, p = 0.03] and 13.6% [5.6 (95% CI 4.9-6.3) vs 6.4 (95% CI 6.3-6.6) pg/ml, p = 0.02] lower among SSRI users compared to non-users, respectively. No differences in SSRI use and markers of bone turnover were detected among older men (61-94 year; all p > 0.05). These patterns persisted after further adjustment for activity, alcohol, smoking, SES, depression, bone active medications and other antidepressants. Our data suggest that SSRI use is associated with alterations in bone turnover markers among younger men. The observed decreases in both CTx and PINP are likely to contribute to a low bone turnover state and increased skeletal fragility with this potential imbalance between formation and resorption resulting in subsequent bone loss. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 46 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 15% |
| Student > Master | 6 | 13% |
| Researcher | 6 | 13% |
| Student > Bachelor | 5 | 11% |
| Student > Postgraduate | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 16 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 26% |
| Nursing and Health Professions | 3 | 7% |
| Social Sciences | 3 | 7% |
| Agricultural and Biological Sciences | 2 | 4% |
| Sports and Recreations | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 19 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2020.
All research outputs
#18,587,406
of 23,023,224 outputs
Outputs from Calcified Tissue International
#1,494
of 1,780 outputs
Outputs of similar age
#334,984
of 446,078 outputs
Outputs of similar age from Calcified Tissue International
#28
of 30 outputs
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