| Title |
Plant-derived antivirals against hepatitis c virus infection
|
|---|---|
| Published in |
Virology Journal, February 2018
|
| DOI | 10.1186/s12985-018-0945-3 |
| Pubmed ID | |
| Authors |
Ana Carolina Gomes Jardim, Jacqueline Farinha Shimizu, Paula Rahal, Mark Harris |
| Abstract |
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for HCV genotype 1. However, the high costs and potential for development of resistance presented by existing treatment demonstrate the need for the development of more efficient new antivirals, or combination of therapies that target different stages of the viral lifecycle. Over the past decades, there has been substantial study of compounds extracted from plants that have activity against a range of microorganisms that cause human diseases. An extensive variety of natural compounds has demonstrated antiviral action worldwide, including anti-HCV activity. In this context, plant-derived compounds can provide an alternative approach to new antivirals. In this review, we aim to summarize the most promising plant-derived compounds described to have antiviral activity against HCV. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 16% |
| Student > Bachelor | 11 | 12% |
| Student > Ph. D. Student | 10 | 11% |
| Researcher | 6 | 7% |
| Student > Postgraduate | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 36 | 40% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 18% |
| Agricultural and Biological Sciences | 9 | 10% |
| Immunology and Microbiology | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Medicine and Dentistry | 3 | 3% |
| Other | 7 | 8% |
| Unknown | 43 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2018.
All research outputs
#6,809,321
of 23,023,224 outputs
Outputs from Virology Journal
#740
of 3,061 outputs
Outputs of similar age
#141,685
of 446,078 outputs
Outputs of similar age from Virology Journal
#8
of 57 outputs
Altmetric has tracked 23,023,224 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 3,061 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 446,078 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.