| Title |
Immunocytochemical demonstration of nerve growth factor receptor (NGF-R) in developing human fetal teeth
|
|---|---|
| Published in |
Brain Structure and Function, September 1993
|
| DOI | 10.1007/bf00188216 |
| Pubmed ID | |
| Authors |
Lars Rosén Christensen, Kjeld Møllgård, Inger Kjær, Mette Stagaard Janas |
| Abstract |
Evidence is accumulating that nerve growth factor receptor (NGF-R or p75NGFR) can mediate cell growth and differentiation of non-neuronal cells. NGF-R expression was studied in developing teeth of human embryos and fetuses between the 6th and 18th weeks of gestation, using a monoclonal mouse-anti-human NGF-R antibody. In contrast to earlier findings in rodents, the NGF-R expression of the human dental papilla was found to be transient. NGF-R was present in the condensing ecto-mesenchymal cells of the dental papilla in the early cap stage tooth germ. In later developmental stages, a shift of the NGF-R expression from the papilla to the cytoplasmic membrane of the inner enamel epithelium (IEE) was demonstrated. As in rodent odontogenesis, the NGF-R immunoreactivity of the IEE remained until the odontoblasts started secretion of predentinal matrix in the late bell state. The mitotic activity in the IEE was detected by an antibody against proliferating cell nuclear antigen (PCNA) and showed that the NGF-R expression of the IEE decreased as the cell proliferation ceased. We propose that NGF-R may, be involved in differential and/or proliferative events of human odontogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 18% |
| Student > Postgraduate | 2 | 18% |
| Student > Ph. D. Student | 2 | 18% |
| Professor > Associate Professor | 2 | 18% |
| Student > Bachelor | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 64% |
| Agricultural and Biological Sciences | 2 | 18% |
| Engineering | 1 | 9% |
| Unknown | 1 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2010.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Brain Structure and Function
#675
of 2,021 outputs
Outputs of similar age
#5,721
of 18,747 outputs
Outputs of similar age from Brain Structure and Function
#1
of 1 outputs
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