| Title |
Pharmacokinetic Study of Zimelidine Using a New GLC Method
|
|---|---|
| Published in |
Clinical Pharmacokinetics, December 2012
|
| DOI | 10.2165/00003088-198308060-00004 |
| Pubmed ID | |
| Authors |
Gilles Caillé, Edouard Kouassi, Claude de Montigny |
| Abstract |
A specific, sensitive, rapid and reproducible analytical method for zimelidine [3-(4-bromophenyl)-N,N-dimethyl-3(3-pyridyl)allylamine] and its biologically active demethylated metabolite, norzimelidine, in human plasma was developed using gas-liquid chromatography (GLC) with loxapine as the internal standard. A good separation of zimelidine and norzimelidine was obtained following derivatisation of norzimelidine with heptafluorobutyric anhydride, the retention times being 6.16 and 10.35 minutes, respectively. The sensitivity of the method is 5 ng/ml for zimelidine and norzimelidine. Plasma concentrations of zimelidine and norzimelidine were determined in 10 healthy volunteers following the administration of a single oral dose of 100mg zimelidine. Zimelidine was rapidly absorbed, giving a mean peak plasma concentration of 103.9 +/- 34.8 ng/ml. The mean plasma elimination half-life was 8.4 +/- 2.0 hours for zimelidine and 19.4 +/- 3.6 hours for norzimelidine. After long term administration of zimelidine (100mg bid for the first week, 100mg tid for the second week and 100mg am and 200mg pm for the third and fourth weeks) to 2 depressed patients, plasma concentrations of norzimelidine were 2 to 4 times higher than those of zimelidine. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 11% |
| Unknown | 8 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 22% |
| Student > Master | 2 | 22% |
| Lecturer | 1 | 11% |
| Professor | 1 | 11% |
| Student > Doctoral Student | 1 | 11% |
| Other | 2 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 22% |
| Medicine and Dentistry | 2 | 22% |
| Agricultural and Biological Sciences | 2 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
| Psychology | 1 | 11% |
| Other | 1 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2020.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Clinical Pharmacokinetics
#682
of 1,602 outputs
Outputs of similar age
#86,788
of 286,287 outputs
Outputs of similar age from Clinical Pharmacokinetics
#144
of 387 outputs
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