| Title |
Dale's principle and glutamate corelease from ventral midbrain dopamine neurons
|
|---|---|
| Published in |
Amino Acids, August 2000
|
| DOI | 10.1007/s007260070032 |
| Pubmed ID | |
| Authors |
D. Sulzer, S. Rayport |
| Abstract |
While direct application of dopamine modulates postsynaptic activity, electrical stimulation of dopamine neurons typically evokes excitation. Most of this excitation appears to be due to activation of collateral pathways; however, several lines of evidence have suggested that there is a monosynaptic component due to glutamate corelease by dopamine neurons. Recently, more direct evidence obtained in culture has shown that ventral midbrain dopamine neurons release both dopamine and glutamate. Moreover, they appear to do so from separate release sites, calling into question recent modifications of Dale's Principle. The neurochemical phenotype of a given synapse may be determined by subcellular neurotransmitter levels, uptake, or storage. However, the relationship between dopamine and glutamate release from dopamine neuron synapses in the intact brain--and the mechanisms involved--has yet to be resolved. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| United Kingdom | 1 | 2% |
| Italy | 1 | 2% |
| Unknown | 53 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 25% |
| Researcher | 11 | 19% |
| Professor | 6 | 11% |
| Professor > Associate Professor | 4 | 7% |
| Student > Doctoral Student | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 37% |
| Neuroscience | 13 | 23% |
| Medicine and Dentistry | 6 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Psychology | 2 | 4% |
| Other | 3 | 5% |
| Unknown | 9 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2023.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Amino Acids
#552
of 1,619 outputs
Outputs of similar age
#12,801
of 38,134 outputs
Outputs of similar age from Amino Acids
#3
of 13 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,619 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.