| Title |
Exploring variability in basal ganglia connectivity with functional MRI in healthy aging
|
|---|---|
| Published in |
Brain Imaging and Behavior, February 2018
|
| DOI | 10.1007/s11682-018-9824-1 |
| Pubmed ID | |
| Authors |
Ludovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C. Klein, Mika Kivimäki, Archana Singh-Manoux, Michele T. Hu, Klaus P. Ebmeier, Clare E. Mackay |
| Abstract |
Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults. We explored the relationship between FC in the BGN and variables related to demographics, impulsive behavior, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches. Age was the only correlate of FC in the BGN that was consistently significant with both analyses. The observed adverse effect of aging on FC may relate to alterations of the dopaminergic system, but no unique dopamine-related function seemed to have a link with FC beyond those detectable in and linearly correlated with healthy aging. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 16 | 59% |
| United States | 5 | 19% |
| Germany | 1 | 4% |
| Finland | 1 | 4% |
| Norway | 1 | 4% |
| Unknown | 3 | 11% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 70% |
| Scientists | 7 | 26% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 16% |
| Student > Bachelor | 8 | 13% |
| Student > Master | 6 | 9% |
| Student > Doctoral Student | 5 | 8% |
| Other | 5 | 8% |
| Other | 12 | 19% |
| Unknown | 18 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 13 | 20% |
| Medicine and Dentistry | 9 | 14% |
| Psychology | 9 | 14% |
| Engineering | 6 | 9% |
| Computer Science | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 20 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2019.
All research outputs
#1,988,755
of 23,322,258 outputs
Outputs from Brain Imaging and Behavior
#93
of 1,156 outputs
Outputs of similar age
#50,636
of 447,690 outputs
Outputs of similar age from Brain Imaging and Behavior
#5
of 36 outputs
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So far Altmetric has tracked 1,156 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.