| Title |
Flexibases: A way to enhance the use of molecular docking methods
|
|---|---|
| Published in |
Perspectives in Drug Discovery and Design, October 1994
|
| DOI | 10.1007/bf00123666 |
| Pubmed ID | |
| Authors |
Simon K. Kearsley, Dennis J. Underwood, Robert P. Sheridan, Michael D. Miller |
| Abstract |
Specially expanded databases containing three-dimensional structures are created to enhance the utility of docking methods to find new leads, i.e., active compounds of pharmacological interest. The expansion is based on the automatic generation of a set of maximally dissimilar conformations. The ligand receptor system of methotrexate and dihydrofolate reductase is used to demonstrate the feasibility of creating flexibases and their utility in docking studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 47 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 24% |
| Student > Master | 10 | 20% |
| Student > Postgraduate | 5 | 10% |
| Student > Bachelor | 4 | 8% |
| Researcher | 4 | 8% |
| Other | 10 | 20% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 20 | 41% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Agricultural and Biological Sciences | 4 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 8% |
| Computer Science | 2 | 4% |
| Other | 9 | 18% |
| Unknown | 5 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2020.
All research outputs
#5,471,255
of 25,457,858 outputs
Outputs from Perspectives in Drug Discovery and Design
#249
of 949 outputs
Outputs of similar age
#2,747
of 20,479 outputs
Outputs of similar age from Perspectives in Drug Discovery and Design
#1
of 5 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 949 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 20,479 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them