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Mendeley readers
Attention Score in Context
| Title |
Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease
|
|---|---|
| Published in |
Acta Neuropathologica, March 2008
|
| DOI | 10.1007/s00401-008-0366-2 |
| Pubmed ID | |
| Authors |
Dietmar Rudolf Thal, W. Sue T. Griffin, Rob A. I. de Vos, Estifanos Ghebremedhin |
| Abstract |
Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid beta-protein (A beta) within cerebral vessels. The involvement of different brain areas in CAA follows a hierarchical sequence similar to that of Alzheimer-related senile plaques. Alzheimer's disease patients frequently exhibit CAA. The expansion of CAA in AD often shows the pattern of full-blown CAA. The deposition of A beta within capillaries distinguishes two types of CAA. One with capillary A beta-deposition is characterized by a strong association with the apolipoprotein E (APOE) epsilon 4 allele and by its frequent occurrence in Alzheimer's disease cases whereas the other one lacking capillary A beta-deposits is not associated with APOE epsilon 4. Capillary CAA can be seen in every stage of CAA or AD-related A beta-deposition. AD cases with capillary CAA show more widespread capillary A beta-deposition than non-demented cases as well as capillary occlusion. In a mouse model of CAA, capillary CAA was associated with capillary occlusion and cerebral blood flow disturbances. Thus, blood flow alterations with subsequent hypoperfusion induced by CAA-related capillary occlusion presumably point to a second mechanism in which A beta adversely affects the brain in AD in addition to its direct neurotoxic effects. |
Mendeley readers
The data shown below were compiled from readership statistics for 255 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 4 | 2% |
| Spain | 3 | 1% |
| South Africa | 2 | <1% |
| Hong Kong | 1 | <1% |
| United Kingdom | 1 | <1% |
| Czechia | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 241 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 48 | 19% |
| Student > Ph. D. Student | 42 | 16% |
| Student > Bachelor | 24 | 9% |
| Student > Master | 22 | 9% |
| Student > Doctoral Student | 18 | 7% |
| Other | 52 | 20% |
| Unknown | 49 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 63 | 25% |
| Neuroscience | 46 | 18% |
| Agricultural and Biological Sciences | 35 | 14% |
| Biochemistry, Genetics and Molecular Biology | 17 | 7% |
| Engineering | 7 | 3% |
| Other | 27 | 11% |
| Unknown | 60 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2023.
All research outputs
#1,753,990
of 23,577,761 outputs
Outputs from Acta Neuropathologica
#375
of 2,407 outputs
Outputs of similar age
#4,322
of 82,282 outputs
Outputs of similar age from Acta Neuropathologica
#2
of 13 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,407 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 82,282 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.