Title |
Associations Between the 2nd to 4th Digit Ratio and Autism Spectrum Disorder in Population-Based Samples of Boys and Girls: Findings from the Study to Explore Early Development
|
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Published in |
Journal of Autism and Developmental Disorders, February 2018
|
DOI | 10.1007/s10803-018-3495-z |
Pubmed ID | |
Authors |
Laura A. Schieve, Lin Tian, Nicole Dowling, Lisa Croen, Julie Hoover-Fong, Aimee Alexander, Stuart K. Shapira |
Abstract |
The ratio of the index (2nd) finger to ring (4th) finger lengths (2D:4D) is a proxy for fetal testosterone and estradiol. Studies suggesting 2D:4D is inversely associated with autism spectrum disorder (ASD) in males were limited by lack of confounder and subgroup assessments. Studies of females are sparse. We examined associations between ASD and 2D:4D among children in the Study to Explore Early Development; we considered case subgroups and numerous potential demographic and maternal-perinatal health confounders. We observed a modest inverse association between ASD and right-hand 2D:4D in males; subgroup analyses indicated associations were limited to ASD cases with birth defects/genetic syndromes or dysmorphic features. We observed a positive association between ASD and left-hand 2D:4D in females, overall and within most case subgroups. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 25% |
United Kingdom | 2 | 25% |
Canada | 1 | 13% |
Georgia | 1 | 13% |
Unknown | 2 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 50% |
Scientists | 2 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 13% |
Researcher | 7 | 13% |
Student > Ph. D. Student | 7 | 13% |
Student > Postgraduate | 3 | 6% |
Student > Doctoral Student | 3 | 6% |
Other | 4 | 8% |
Unknown | 22 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 10 | 19% |
Neuroscience | 4 | 8% |
Nursing and Health Professions | 3 | 6% |
Social Sciences | 3 | 6% |
Medicine and Dentistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 26 | 49% |