| Title |
BDNF effects on dendritic spine morphology and hippocampal function
|
|---|---|
| Published in |
Cell and Tissue Research, February 2018
|
| DOI | 10.1007/s00441-017-2782-x |
| Pubmed ID | |
| Authors |
Oliver von Bohlen und Halbach, Viola von Bohlen und Halbach |
| Abstract |
Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal through specific tyrosine kinase receptors and the low affinity receptor p75NTR. Moreover, the pro-neurotrophins are considered to be biologically active by signaling through specific receptors. The neurotrophins, especially BDNF, are involved in processes related to learning and memory. Furthermore, it is thought that BDNF also plays a crucial role in major depression. This points to a role of BDNF as a central regulator of neuronal plasticity within the postnatal hippocampus. Morphological correlates of neuronal plasticity are changes on the level of the dendritic spines and, at least in the dentate gyrus of the hippocampus, on the level of adult neurogenesis. Specific changes in dendritic spines as well as in adult hippocampal neurogenesis can be seen in the context of several forms of learning and memory, and it is known that depression is accompanied by declines in the rate of adult neurogenesis and in spine densities. The possible roles of BDNF in neuronal plasticity within the hippocampus are highlighted in this review by focusing on the morphological components of neuronal plasticity. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 213 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 213 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 17% |
| Student > Bachelor | 31 | 15% |
| Researcher | 25 | 12% |
| Student > Master | 25 | 12% |
| Student > Doctoral Student | 17 | 8% |
| Other | 22 | 10% |
| Unknown | 56 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 63 | 30% |
| Biochemistry, Genetics and Molecular Biology | 22 | 10% |
| Agricultural and Biological Sciences | 14 | 7% |
| Medicine and Dentistry | 12 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
| Other | 24 | 11% |
| Unknown | 71 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2021.
All research outputs
#14,900,673
of 23,839,820 outputs
Outputs from Cell and Tissue Research
#1,367
of 2,279 outputs
Outputs of similar age
#265,329
of 478,532 outputs
Outputs of similar age from Cell and Tissue Research
#19
of 43 outputs
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