| Title |
“Silent” Diabetes and Clinical Outcome After Treatment With Contemporary Drug-Eluting Stents The BIO-RESORT Silent Diabetes Study
|
|---|---|
| Published in |
JACC: Cardiovascular Interventions, February 2018
|
| DOI | 10.1016/j.jcin.2017.10.038 |
| Pubmed ID | |
| Authors |
Clemens von Birgelen, Marlies M Kok, Naveed Sattar, Paolo Zocca, Cees Doelman, Gert D Kant, Marije M Löwik, Liefke C van der Heijden, Hanim Sen, K Gert van Houwelingen, Martin G Stoel, J Hans W Louwerenburg, Marc Hartmann, Frits H A F de Man, Gerard C M Linssen, Carine J M Doggen, Kenneth Tandjung |
| Abstract |
This study sought to assess the prevalence and clinical impact of silent diabetes and pre-diabetes in "nondiabetic" percutaneous coronary intervention (PCI) all-comers. Patients with undetected and thus untreated (silent) diabetes may have higher event risks after PCI with contemporary drug-eluting stents (DES). The BIO-RESORT Silent Diabetes study, performed at Thoraxcentrum Twente, is a substudy of the randomized multicenter BIO-RESORT (BIOdegradable Polymer and DuRable Polymer Drug-eluting Stents in an All COmeRs PopulaTion) trial (NCT01674803). Patients underwent oral glucose tolerance testing (OGTT), and assessment of glycosylated hemoglobin with fasting plasma glucose. Primary endpoint was a composite of cardiac death, target vessel-related myocardial infarction, or target vessel revascularization at 1 year. Of the 988 participants, OGTT detected silent diabetes in 68 (6.9%), pre-diabetes in 133 (13.3%), and normal glucose metabolism in 788 (79.8%). Patients with silent diabetes had higher primary endpoint rates (13.2% vs. 7.6% vs. 4.8%; p < 0.001; silent diabetes vs. normal: hazard ratio: 4.2; 95% confidence interval: 1.9 to 9.2). Differences were driven by myocardial infarction (p < 0.001) which occurred mostly <48 h. Based on glycosylated hemoglobin and fasting plasma glucose, silent diabetes was found in 33 (3.3%) patients, pre-diabetes in 217 (22.0%) patients, and normal glucose metabolism in 738 (74.7%) patients; primary endpoint rates were similar to OGTT-based analyses (12.1% vs. 5.5% vs. 3.1%; p = 0.01). Multivariate analyses demonstrated that abnormal glucose metabolism by either diagnostic approach, present in 330 (33.4%) patients, independently predicted adverse event risk (hazard ratio: 2.2; 95% confidence interval: 1.2 to 4.2). Abnormal glucose metabolism was detected in 1 of 3 "nondiabetic" PCI patients and was independently associated with up to 4-fold higher event risks. Future intervention trials should determine whether meaningful benefits accrue from routine glycemia testing in such patients. |
X Demographics
The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 4 | 17% |
| United Kingdom | 3 | 13% |
| United States | 2 | 8% |
| Comoros | 1 | 4% |
| Ireland | 1 | 4% |
| Mexico | 1 | 4% |
| Spain | 1 | 4% |
| Unknown | 11 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 67% |
| Practitioners (doctors, other healthcare professionals) | 4 | 17% |
| Scientists | 4 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 9% |
| Student > Postgraduate | 5 | 8% |
| Student > Ph. D. Student | 5 | 8% |
| Student > Master | 4 | 6% |
| Researcher | 3 | 5% |
| Other | 11 | 17% |
| Unknown | 30 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 39% |
| Nursing and Health Professions | 5 | 8% |
| Unspecified | 1 | 2% |
| Earth and Planetary Sciences | 1 | 2% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 29 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2018.
All research outputs
#1,106,211
of 25,382,440 outputs
Outputs from JACC: Cardiovascular Interventions
#438
of 4,032 outputs
Outputs of similar age
#27,144
of 455,332 outputs
Outputs of similar age from JACC: Cardiovascular Interventions
#9
of 88 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.