| Title |
RETRACTED ARTICLE: pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation
|
|---|---|
| Published in |
Drug Delivery and Translational Research, February 2018
|
| DOI | 10.1007/s13346-018-0486-8 |
| Pubmed ID | |
| Authors |
Syed Ahmed Shah, Muhammad Sohail, Muhammad Usman Minhas, Nisar-ur-Rehman, Shahzeb Khan, Zahid Hussain, Mudassir, Arshad Mahmood, Mubeen Kousar, Asif Mahmood |
| Abstract |
Cellulose acetate phthalate-based pH-responsive hydrogel was synthesized for fabrication of polymeric matrix tablets for gastro-protective delivery of loxoprofen sodium. Cellulose acetate phthalate (CAP) was cross-linked with methacrylic acid (MAA) using free radical polymerization technique. Fourier transform infrared (FTIR) spectra confirmed the formation of cross-linked structure of CAP-co-poly(methacrylic acid). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the thermal stability of polymeric networks, and scanning electron microscopy (SEM) and energy-dispersive X-ray spectrum (EDS) images unveiled that the prepared formulations were porous in nature and thus the developed formulations had shown better diffusibility. Swelling and in vitro drug release was performed at various pHs and maximum swelling and release was obtained at pH 7.4, while swelling and release rate was very low at pH 1.2 which confirmed the pH-responsive behavior of CAP-co-poly(MAA). CAP-co-poly(MAA) copolymer prevents the release of loxoprofen sodium into the stomach due to reduced swelling at gastric pH while showing significant swelling and drug release in the colon. Cytotoxicity studies revealed higher biocompatibility of fabricated hydrogel. Acute oral toxicity studies were performed for the evaluation and preliminary screening of safety profile of the developed hydrogels. Matrix tablets were evaluated for release behavior at simulated body pH. The investigations performed for analysis of hydrogels and fabricated matrix tablets indicated the controlled drug release and gastro-protective drug delivery of CAP-co-poly(MAA) hydrogels and pH-sensitive matrix tablets for targeted delivery of gastro-sensitive/irritative agents. Graphical abstract ᅟ. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Pakistan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 16% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Postgraduate | 3 | 7% |
| Professor > Associate Professor | 3 | 7% |
| Researcher | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 19 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 18% |
| Chemistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Chemical Engineering | 1 | 2% |
| Medicine and Dentistry | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 25 | 57% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2018.
All research outputs
#15,492,327
of 23,023,224 outputs
Outputs from Drug Delivery and Translational Research
#326
of 516 outputs
Outputs of similar age
#291,593
of 474,288 outputs
Outputs of similar age from Drug Delivery and Translational Research
#12
of 18 outputs
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So far Altmetric has tracked 516 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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