| Title |
Exposure to maternal cafeteria diets during the suckling period has greater effects on fat deposition and Sterol Regulatory Element Binding Protein-1c (SREBP-1c) gene expression in rodent offspring compared to exposure before birth
|
|---|---|
| Published in |
Nutrition & Metabolism, February 2018
|
| DOI | 10.1186/s12986-018-0253-3 |
| Pubmed ID | |
| Authors |
M. A. Vithayathil, J. R. Gugusheff, Z. Y. Ong, S. C. Langley-Evans, R. A. Gibson, B. S. Muhlhausler |
| Abstract |
While the adverse metabolic effects of exposure to obesogenic diets during both the prenatal and early postnatal period are well established, the relative impact of exposure during these separate developmental windows remains unclear. This study aimed to assess the relative contribution of exposure to a maternal cafeteria diet during pregnancy and lactation on body weight, fat mass and expression of lipogenic and adipokine genes in the offspring. Wistar rats were fed either a control chow (Control,n = 14) or obesogenic cafeteria diet (CAF,n = 12) during pregnancy and lactation. Pups were cross-fostered to another dam in either the same or different dietary group within 24 h of birth. Body weight, body fat mass and expression of lipogenic and adipokine genes in subcutaneous and visceral adipose tissues were determined in offspring at weaning and 3 weeks post-weaning. Offspring suckled by CAF dams had a lower body weight (P < 0.05), but ~ 2-fold higher percentage body fat at weaning than offspring suckled by Control dams (P < 0.01), independent of whether they were born to a Control or CAF dam. At 6 weeks of age, after all offspring were weaned onto standard chow, males and females suckled by CAF dams remained lighter (P < 0.05) than offspring suckled by Control dams, but the percentage fat mass was no longer different between groups. Sterol Regulatory Element Binding Protein-1c (SREBP-1c) mRNA expression was ~ 25% lower in offspring suckled by cafeteria dams in males at weaning (P < 0.05) and in females at 6 weeks of age (P < 0.05). Exposure to a cafeteria diet during the suckling period alone also resulted in increased adipocyte Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) mRNA expression in females, and adiponectin and leptin mRNA expression in both sexes at weaning. The findings from this study point to the critical role of the suckling period for deposition of adipose tissue in rodents, and the potential role of altered adipocyte gene expression in mediating these effects. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 7 | 44% |
| Canada | 4 | 25% |
| United States | 3 | 19% |
| Spain | 1 | 6% |
| United Kingdom | 1 | 6% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 10 | 63% |
| Members of the public | 5 | 31% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 16% |
| Researcher | 5 | 9% |
| Student > Bachelor | 5 | 9% |
| Student > Ph. D. Student | 5 | 9% |
| Student > Doctoral Student | 3 | 5% |
| Other | 7 | 13% |
| Unknown | 22 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Medicine and Dentistry | 8 | 14% |
| Nursing and Health Professions | 4 | 7% |
| Agricultural and Biological Sciences | 2 | 4% |
| Unspecified | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 26 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2023.
All research outputs
#1,889,240
of 24,696,958 outputs
Outputs from Nutrition & Metabolism
#236
of 996 outputs
Outputs of similar age
#48,867
of 484,107 outputs
Outputs of similar age from Nutrition & Metabolism
#5
of 17 outputs
Altmetric has tracked 24,696,958 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 996 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 484,107 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.