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Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling

Overview of attention for article published in Cancer Research, December 2010
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

patent
1 patent
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
354 Dimensions

Readers on

mendeley
171 Mendeley
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1 Connotea
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Title
Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling
Published in
Cancer Research, December 2010
DOI 10.1158/0008-5472.can-10-0881
Pubmed ID
Authors

James P. Sullivan, Monica Spinola, Michael Dodge, Maria G. Raso, Carmen Behrens, Boning Gao, Katja Schuster, Chunli Shao, Jill E. Larsen, Laura A. Sullivan, Sofia Honorio, Yang Xie, Pier P. Scaglioni, J. Michael DiMaio, Adi F. Gazdar, Jerry W. Shay, Ignacio I. Wistuba, John D. Minna

Abstract

Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-like properties. Immunohistochemical staining of a large panel of primary non-small cell lung cancer (NSCLC) samples for ALDH1A1, ALDH3A1, and CD133 revealed a significant correlation between ALDH1A1 (but not ALDH3A1 or CD133) expression and poor prognosis in patients including those with stage I and N0 disease. Flow cytometric analysis of a panel of lung cancer cell lines and patient tumors revealed that most NSCLCs contain a subpopulation of cells with elevated ALDH activity, and that this activity is associated with ALDH1A1 expression. Isolated ALDH(+) lung cancer cells were observed to be highly tumorigenic and clonogenic as well as capable of self-renewal compared with their ALDH(-) counterparts. Expression analysis of sorted cells revealed elevated Notch pathway transcript expression in ALDH(+) cells. Suppression of the Notch pathway by treatment with either a γ-secretase inhibitor or stable expression of shRNA against NOTCH3 resulted in a significant decrease in ALDH(+) lung cancer cells, commensurate with a reduction in tumor cell proliferation and clonogenicity. Taken together, these findings indicate that ALDH selects for a subpopulation of self-renewing NSCLC stem-like cells with increased tumorigenic potential, that NSCLCs harboring tumor cells with ALDH1A1 expression have inferior prognosis, and that ALDH1A1 and CD133 identify different tumor subpopulations. Therapeutic targeting of the Notch pathway reduces this ALDH(+) component, implicating Notch signaling in lung cancer stem cell maintenance.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 2%
Portugal 1 <1%
Denmark 1 <1%
Iran, Islamic Republic of 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 162 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 23%
Researcher 37 22%
Student > Master 27 16%
Student > Bachelor 17 10%
Student > Doctoral Student 12 7%
Other 19 11%
Unknown 19 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 29%
Biochemistry, Genetics and Molecular Biology 37 22%
Medicine and Dentistry 37 22%
Engineering 7 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 14 8%
Unknown 21 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2020.
All research outputs
#4,696,096
of 22,786,087 outputs
Outputs from Cancer Research
#4,601
of 17,868 outputs
Outputs of similar age
#31,247
of 180,469 outputs
Outputs of similar age from Cancer Research
#61
of 206 outputs
Altmetric has tracked 22,786,087 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,868 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,469 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 206 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.